Recent Progress of N,N-Dimethylformamide (DMF) as Versatile Synthons in Organic Synthesis

IF 8.8 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2026-04-09 DOI:10.1007/s41061-026-00543-1

Hao Lu, Meng Yu, Xiaohui Tian, Xiaorong Suo, Xiaomei Hei, Juan Yang, Jianqi Yao, Renhua Qiu

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Abstract

N,N-Dimethylformamide (DMF), as an indispensable and versatile reagent in organic synthesis, has evolved from a traditional solvent to a synthetic building block with rich reactivity. Due to its unique molecular structure, DMF can participate in the construction of various complex organic molecules through multiple reaction pathways under different reaction conditions. Accordingly, this review aims to provide a comprehensive and in-depth summary of the latest research progress in organic synthesis using DMF as a versatile synthon, covering all relevant literature reports published between May 1, 2020, and May 1, 2025. Furthermore, in-depth studies of the underlying reaction mechanisms help to precisely understand the essence of DMF’s involvement in reactions, thereby providing a solid theoretical foundation for optimizing reaction conditions and developing novel reaction pathways. This review serves as a crucial reference guide for expanding the application scope of DMF in organic synthesis and developing more environmentally friendly organic synthesis methods.

Graphical Abstract

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N，N-二甲基甲酰胺（DMF）在有机合成中的研究进展

N，N-二甲基甲酰胺（DMF）作为有机合成中不可缺少的多用途试剂，已从传统的溶剂发展成为具有丰富反应活性的合成基石。由于其独特的分子结构，DMF可以在不同的反应条件下通过多种反应途径参与各种复杂有机分子的构建。因此，本文旨在全面、深入地综述利用DMF作为多功能合成物进行有机合成的最新研究进展，涵盖2020年5月1日至2025年5月1日期间发表的所有相关文献报道。进一步深入研究反应机制有助于准确理解DMF参与反应的本质，从而为优化反应条件和开发新的反应途径提供坚实的理论基础。本文综述对扩大DMF在有机合成中的应用范围，开发更环保的有机合成方法具有重要的参考指导意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.