Association of Green Tea Consumption and the Risk of Liver Cancer Incidence among Japanese Adults.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2026-04-01 DOI:10.31557/APJCP.2026.27.4.1313

Ohiroshi Funabashi, Ryoto Sakaniwa, Ryo Kawasaki, Akiko Tamakoshi, Hiroyasu Iso

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引用次数: 0

Abstract

Background: The association between green tea consumption and the risk of liver cancer has been reported inconsistently. This study aimed to investigate this association in a large, prospective cohort study of Japanese adults. Methods: The Japan Collaborative Cohort (JACC) Study included 41,999 participants (18,205 men and 23794 women) aged 40-79 years, free from liver cancer at baseline between 1988 and 1990. Validated self-administered questionnaires were used to assess individual socio-demographics, medical history, and lifestyles. Participants were then followed for liver cancer incidence until the end of 2009. Cox proportional hazard models were utilized to calculate hazard ratios (HRs) with 95% confidence intervals (95% CIs) of liver cancer based on the frequency of green tea consumption of <1 cup (reference), 2-4, 5-6, and ≥7 cups/day, after adjusting for potential confounding factors, including age, sex, study area, education, histories of diabetes, liver diseases, and gallbladder disease, body mass index, drinking status, smoking status, coffee consumption, sports participation, and walking. Major confounders, including coffee consumption, drinking status, and a history of liver disease, were further stratified in the analysis. Population-attributable fractions (PAFs) of liver cancer was also calculated based on green tea consumption.

Results: Green tea consumption was associated with a trend of lower risk of liver cancer with the multivariable HR (95% CI) of 0.87 (0.61-1.23) for 2-4 cups/day, 0.87 (0.61-1.25) for 5-6 cups/day, and 0.61 (0.40-0.95) for ≥7 cups/day, compared to <1 cup/day (p for trend= 0.029). The inverse association was statistically significant for men, people without a history of liver diseases other than cancer, and current drinkers. The multivariable PAF (95%CI) for ≥7 cups/day was 7.1% (0.9-11.4).

Conclusion: Green tea consumption was associated with a lower risk of liver cancer in Japanese adults in a dose-response manner, ranging from <1 cup/day to ≥7 cups/day.

查看原文本刊更多论文

绿茶消费与日本成年人肝癌发病率的关系。

背景：绿茶消费与肝癌风险之间的关系一直被报道得不一致。本研究旨在通过一项针对日本成年人的大型前瞻性队列研究来调查这种关联。方法：日本协作队列（JACC）研究包括41999名参与者（18205名男性和23794名女性），年龄在40-79岁之间，在1988年至1990年期间基线无肝癌。使用有效的自我管理问卷来评估个人社会人口统计学、病史和生活方式。然后跟踪调查参与者的肝癌发病率，直到2009年底。结果：2-4杯/天、5-6杯/天、0.87（0.61-1.25）、≥7杯/天饮用绿茶与肝癌风险降低趋势相关，多变量风险比（95% CI）为0.87（0.61- 0.95）、0.61（0.40-0.95）。在日本成年人中，绿茶消费与较低的肝癌风险呈剂量反应关系，范围从

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.