Enhanced therapeutic potential of folic acid-tagged targeted liposomal quercetin (Lipo-Que) over Free-Que in Benzo [a] pyrene-induced lung cancer in mice.
Jenitha Vincent, David Wilson, Monith Gnanaselvam, Kokelavani Nampalli Babu, Srividhya Muralidharan, Nandana Vijay, Viswanathan Sundaram, Ramachandra Dilip, Harish Ugendar, V M Berlin Grace
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引用次数: 0
Abstract
Aims: The anti-cancer potency of quercetin is limited by poor intestinal absorption and rapid metabolism clearance. This study was designed to analyze therapeutic efficacy of liposome nano-formulation of quercetin in experimental lung cancer when administered intravenously and compare it with a molecular drug, liposomal sorafenib.
Materials and methods: The Lipo-Que and Lipo-Sorafenib were prepared by thin film formation method and administered to Benzo (a) Pyrene induced lung cancer mice. The mean survival time and other therapeutic effects in vivo were evaluated. Apoptosis induction in lung tissue ex vivo was quantified using Flow cytometry analysis.
Results: The Lipo-Que significantly prolonged the lifespan of cancer-induced mice (MST: 310.86 ± 0.58 days) compared to cancer control (210.18 ± 0.00 days) and Free-Que-treated mice. It significantly reduced the tumor foci and histopathologic changes in lungs and liver with complete elimination of liver metastasis. A highly significant reduction (p ≤ 0.001) in the hematopathology changes of cancer with early apoptosis induction (19.47 ± 0.00%) was observed in the Lipo-Que group, which signifies its non-inflammatory clearance of cancer cells.
Conclusions: Lipo-Que exhibits superior therapeutic efficacy compared to Free-Que, highlighting its targeted delivery and action as a promising and safe alternative to conventional mode of quercetin therapy, opening avenues for further translational development.
期刊介绍：
Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.
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