Mechanistic insights and ameliorative strategies: advances in DEHP-induced metabolic toxicity and intervention by natural bioactive compounds and probiotics.
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引用次数: 0
Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is a ubiquitous plasticizer and environmental contaminant linked to severe metabolic disorders. This review concisely elucidates the multi-organ mechanisms of DEHP-induced toxicity, highlighting its disruption of lipid, glucose, and protein homeostasis. Specifically, we delineate the crucial crosstalk between oxidative stress, endoplasmic reticulum (ER) stress, and inflammatory pathways that drive DEHP pathobiology. Furthermore, we systematically evaluate emerging ameliorative strategies, focusing on natural bioactive compounds and probiotics. We highlight how these interventions mitigate DEHP toxicity by targeting specific molecular hubs (e.g., PPARs, Nrf2) and restoring gut microbiota balance. By integrating mechanistic insights with natural interventions, this review provides a targeted framework for developing therapeutic countermeasures against phthalate-induced metabolic disruption.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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