Carcinogenicity Risk Assessment of Agrochemicals and Pharmaceuticals.

IF 1.8 4区 医学 Q3 PATHOLOGY
Xavier Palazzi, Samuel M Cohen, Stephanie Melching-Kollmuss, Thomas Nolte, Frederic Schorsch, Kris Siezen, Douglas Wolf, Lindsay Wright
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引用次数: 0

Abstract

The last session of the 2025 Second Joint Congress of the British Society of Toxicological Pathology (BSTP) and the European Society of Toxicologic Pathology (ESTP) held in Manchester (United Kingdom) reviewed current recommendations and best practices for carcinogenicity risk assessment. The session comprised an introductory lecture about new approaches for screening for carcinogenicity, a joint session presenting a regulatory perspective about the Weight of Evidence (WoE) assessment for agrochemicals and pharmaceuticals, followed by another joint session elaborating on the industry experience about WoE. In addition, 3 case examples were presented to illustrate the challenges of in vivo carcinogenicity assessment in rodents within the current paradigm.

农用化学品和药品致癌性风险评估。
在曼彻斯特(英国)举行的2025年英国毒理学病理学学会(BSTP)和欧洲毒理学病理学学会(ESTP)第二届联合大会的最后一次会议审查了目前关于致癌性风险评估的建议和最佳做法。会议包括一个关于筛选致癌性的新方法的介绍性讲座,一个联合会议介绍了农用化学品和药品的证据权重(WoE)评估的监管观点,然后是另一个联合会议详细阐述了WoE的行业经验。此外,还提出了3个案例,以说明在当前范式下对啮齿动物进行体内致癌性评估的挑战。
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来源期刊
Toxicologic Pathology
Toxicologic Pathology 医学-病理学
CiteScore
4.70
自引率
20.00%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Toxicologic Pathology is dedicated to the promotion of human, animal, and environmental health through the dissemination of knowledge, techniques, and guidelines to enhance the understanding and practice of toxicologic pathology. Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology.
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