Association of retinal microvascular abnormalities with cardiovascular diseases in patients with severe carotid artery stenosis.

IF 3.2 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

International Journal of Medical Sciences Pub Date : 2026-03-17 eCollection Date: 2026-01-01 DOI:10.7150/ijms.126670

Li Zhang, Qi-Bo Ran, Chun-Yan Lei, Fei-Peng Jiang, Tian-Yu Yang, Zhi-Hao Xiao, Sheng Gao, Mei-Xia Zhang

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引用次数: 0

Abstract

Purpose: To investigate and summarize the characteristics of retinal microvascular abnormalities (RMAs) in patients with severe carotid artery stenosis (CAS) and explore the association between the presence of RMAs and cardiovascular diseases (CVD).

Methods: Color fundus photography and wide-field swept-source optical coherence tomography angiography (SS-OCTA) examinations were performed on all participants. Images were reviewed to identify RMAs. The occurrence and characteristics of RMAs were summarized. CAS patients with or without CVD were divided into different groups, and the association between the presence of RMAs and CVD were explored using multivariable logistic regression analysis.

Results: This observational, cross-sectional study included 258 eyes from 129 patients with severe CAS. A total of 39/129 patients (30.2%) were identified with RMAs. These RMAs included branch retinal artery occlusion, asymptomatic retinal emboli, cotton wool spots, retinal hemorrhage, branch retinal vein occlusion, inner retinal layer hyperreflectivity, retinal nonperfusion and neovascularization of the optic disk. Multivariable logistic regression analysis revealed that RMAs was significantly associated with the presence of CVD in patients with severe CAS.

Conclusions: This cross-sectional study summarized the characteristics of RMAs associated with CAS and identified RMAs as biomarkers of CVD in patients with severe CAS. Patients with RMAs were at high risk and should be carefully managed.

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颈动脉严重狭窄患者视网膜微血管异常与心血管疾病的关系

目的：探讨颈动脉严重狭窄（CAS）患者视网膜微血管异常（RMAs）的特点，探讨RMAs与心血管疾病（CVD）的关系。方法：对所有参与者进行彩色眼底摄影和宽视场扫描源光学相干断层血管造影（SS-OCTA）检查。检查图像以识别rma。综述了rma的发生及特点。将合并或不合并CVD的CAS患者分为不同组，采用多变量logistic回归分析探讨RMAs与CVD的相关性。结果：这项观察性横断面研究纳入了129例严重CAS患者的258只眼。129例患者中有39例（30.2%）被确定为rma。这些rma包括视网膜分支动脉闭塞、无症状视网膜栓塞、棉毛斑、视网膜出血、视网膜分支静脉闭塞、视网膜内层高反射光、视网膜非灌注和视盘新生血管。多变量logistic回归分析显示，严重CAS患者的rma与CVD存在显著相关。结论：这项横断面研究总结了与CAS相关的rma的特征，并确定了rma是严重CAS患者CVD的生物标志物。rma患者是高危患者，应谨慎治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

7.20

自引率

0.00%

发文量

185

审稿时长

2.7 months

期刊介绍： Original research papers, reviews, and short research communications in any medical related area can be submitted to the Journal on the understanding that the work has not been published previously in whole or part and is not under consideration for publication elsewhere. Manuscripts in basic science and clinical medicine are both considered. There is no restriction on the length of research papers and reviews, although authors are encouraged to be concise. Short research communication is limited to be under 2500 words.