Tracing a Decade of Tilapia Lake Virus Research: Breakthroughs, Challenges, and Projections

Abstract

Tilapia are one of the most farmed fish groups worldwide, with global production exceeding 6.55 million tons in 2022, generating an estimated market value of approximately USD 20.9 billion. Tilapia are favored for their fast growth rate, adaptability to various farming environments, and high nutritional value as a protein source. However, the tilapia industry has encountered a significant challenge with the emergence of tilapia lake virus (TiLV), first noted in 2014. This highly contagious virus has the potential to devastate tilapia populations, leading to substantial economic losses and raising serious concerns about food security in countries reliant on this fish for livelihoods and sustenance. The rapid spread of TiLV and its significant impact on the tilapia industry have led to widespread concerns among stakeholders, researchers, and policymakers. In response, there has been an increasing focus on research and development of effective strategies to control and manage TiLV infections. This review paper aims to provide a comprehensive overview of the substantial advancements in the understanding of TiLV, delving into its genetic variation and manipulation, molecular pathogenesis, epidemiology, transmission pathways, clinical signs, diagnosis, and the underlying pathogenesis of the virus. Additionally, we summarize the current knowledge on the potential impact of TiLV on the global tilapia industry and the measures being implemented to control its spread. Finally, we discuss ongoing scientific efforts toward the development of vaccines and other innovative strategies for effectively managing TiLV infections, highlighting the importance of continued research to secure the future of tilapia aquaculture on a global scale.