Cellular therapies in systemic Sclerosis: immunopathogenesis-informed precision targeting with CAR-T and CAR-NK approaches

IF 7 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-03-01 Epub Date: 2026-04-03 DOI:10.1016/j.berh.2026.102139

Gerard Convey , Masataka Kuwana , Mandana Nikpour

引用次数: 0

Abstract

Systemic sclerosis (SSc) is a rare, heterogeneous systemic autoimmune rheumatic disease characterized by immune dysregulation, vasculopathy, and excessive fibrosis. SSc is associated with high morbidity and mortality despite current immunosuppressive and anti-fibrotic therapies. Emerging cellular therapies, particularly chimeric antigen receptor (CAR) T-cell and natural killer (NK) cell approaches offer potential for deep immune reset and long-term remission. This review examines the immunobiological rationale for these therapies in SSc and evaluates their early clinical evidence, including comparisons to other autoimmune diseases.

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系统性硬化症的细胞治疗：CAR-T和CAR-NK方法的免疫发病机制信息精确靶向。

系统性硬化症（SSc）是一种罕见的异质系统性自身免疫性风湿病，以免疫失调、血管病变和过度纤维化为特征。尽管目前有免疫抑制和抗纤维化治疗，但SSc仍与高发病率和死亡率相关。新兴的细胞疗法，特别是嵌合抗原受体（CAR） t细胞和自然杀伤细胞（NK）方法提供了深度免疫重置和长期缓解的潜力。这篇综述探讨了这些治疗SSc的免疫生物学原理，并评估了它们的早期临床证据，包括与其他自身免疫性疾病的比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.