Brain atrophy in multiple sclerosis: Mechanisms, measurement, and clinical translation.

IF 2.3 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2026-04-02 DOI:10.1016/j.neurol.2026.03.005

I Koubiyr, M M Schoonheim

引用次数: 0

Abstract

Multiple sclerosis (MS) features extensive neurodegenerative pathology, in addition to the well-known neuro-inflammatory lesions. Recent breakthroughs highlight the importance of slow physical and cognitive progression in MS, which can continue despite effective slowing of lesion formation through high efficacy treatment. These types of progression seem driven to a large extent by neurodegenerative changes in MS, highlighting the need for more research to achieve clinical implementation with clear cut-off scores and monitoring strategies. This mini review outlines possible mechanisms underlying neurodegeneration, how to measure these processes on MRI and how we can move towards implementation.

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多发性硬化症的脑萎缩：机制、测量和临床翻译。

多发性硬化症（MS）除了众所周知的神经炎性病变外，还具有广泛的神经退行性病理。最近的突破强调了MS缓慢的身体和认知进展的重要性，尽管通过高效治疗有效地减缓了病变的形成，但这种进展可以持续下去。这些类型的进展似乎在很大程度上是由多发性硬化症的神经退行性改变驱动的，强调需要更多的研究来实现临床实施，明确的截止评分和监测策略。这篇简短的综述概述了神经退行性变的可能机制，如何在MRI上测量这些过程以及我们如何朝着实施的方向发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.