Retinoic acid at the crossroads of reproduction and sleep: an underexplored link with clinical implications.

IF 3.7 3区生物学 Q1 DEVELOPMENTAL BIOLOGY

Reproduction Pub Date : 2026-04-05 DOI:10.1093/reprod/xaag043

Tathiana A Alvarenga, Bianca Camilo Schimenes, Ellen M S Xerfan, Sergio Tufik, Monica L Andersen

引用次数: 0

Abstract

Retinoic acid, a vitamin A derivative widely used in dermatology, plays essential roles in female and male reproductive physiology and in the regulation of circadian rhythms. Emerging evidence suggests that chronic exposure to systemic retinoids, such as isotretinoin, may influence fertility parameters and sleep-reproductive interactions, highlighting the need for greater clinical awareness and longitudinal safety studies.

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维甲酸在生殖和睡眠的十字路口：与临床意义的未充分探索的联系。

视黄酸是一种维生素a衍生物，广泛应用于皮肤病学，在女性和男性生殖生理和昼夜节律调节中发挥重要作用。新出现的证据表明，长期暴露于全身类维甲酸，如异维甲酸，可能会影响生育参数和睡眠-生殖相互作用，强调需要提高临床意识和纵向安全性研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproduction 生物-发育生物学

CiteScore

7.40

自引率

2.60%

发文量

199

审稿时长

4-8 weeks

期刊介绍： Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.