Cui Yu, Chaoqun Xiong, Kang Xie, Zuyao Chen, Enqi Liu, Lizhuo Wang, Jialin Gao
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引用次数: 0
Abstract
Background: Diabetic kidney disease (DKD), a major microvascular complication of diabetes, is increasingly recognized as a chronic inflammatory disorder driven by immune dysregulation.
Summary: This review examines key immunogenetic pathways in DKD, focusing on genetic variants affecting innate and adaptive immunity. We explore how polymorphisms in genes regulating immune cell function, cytokine production, and inflammatory signaling contribute to renal damage. Recent evidence demonstrates that these immunogenetic factors significantly influence DKD development and progression.
Key messages: The pathogenesis of DKD is profoundly influenced by an individual's genetic predisposition to immune dysregulation. Numerous genetic variants can exacerbate inflammatory responses, promoting disease development. A deeper understanding of these immunogenetic pathways not only clarifies the pathophysiology of DKD but also opens avenues for novel biomarker discovery and the development of targeted, personalized immunomodulatory therapies.
期刊介绍：
''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.
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