NECROHEMORRHAGIC MENINGOENCEPHALITIS IN A RED RUFFED LEMUR (VARECIA RUBRA) CAUSED BY ACANTHAMOEBA T1 GENOTYPE.

IF 0.5 4区 农林科学 Q3 VETERINARY SCIENCES
Hunter Ferchaw, Bayla Bessemer, Sasha Dixon, Rory C Chien, Jana M Ritter, Ibne Karim M Ali, Shantanu Roy, Kathryn E Seeley
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引用次数: 0

Abstract

A 5-yr-old castrated male red ruffed lemur (Varecia rubra) was evaluated for cluster seizures over a 24-h period. Seizures were refractory to anticonvulsive therapy. MRI revealed meningoencephalitis affecting the left occipital lobe. Because of concern for superrefractory status epilepticus and overall poor prognosis, the animal was humanely euthanized. Postmortem examination revealed necrohemorrhagic meningoencephalitis with intralesional amoebic trophozoites and cysts. The causative agent was identified as Acanthamoeba spp. T1 genotype via immunohistochemistry staining and species-specific real-time PCR. To the authors' knowledge, this is the first documented report of Acanthamoeba T1 genotype meningoencephalitis in a nonhuman primate in professional care.

由棘阿米巴t1基因型引起的红皱褶狐猴坏死性出血性脑膜脑炎。
对一只5岁雄性阉割红颈狐猴进行了24小时的丛集性癫痫发作评估。抗惊厥治疗对癫痫发作难治。MRI显示脑膜脑炎累及左枕叶。由于考虑到异常难治性癫痫持续状态和整体预后不良,动物被人道安乐死。死后检查发现坏死出血性脑膜脑炎伴病灶内阿米巴滋养体和囊肿。经免疫组织化学染色和实时荧光定量PCR鉴定,病原菌为棘阿米巴T1基因型。据作者所知,这是在专业护理的非人灵长类动物中首次记录棘阿米巴T1基因型脑膜脑炎的报告。
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来源期刊
Journal of Zoo and Wildlife Medicine
Journal of Zoo and Wildlife Medicine 农林科学-兽医学
CiteScore
1.70
自引率
14.30%
发文量
74
审稿时长
9-24 weeks
期刊介绍: The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.
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