Hunter Ferchaw, Bayla Bessemer, Sasha Dixon, Rory C Chien, Jana M Ritter, Ibne Karim M Ali, Shantanu Roy, Kathryn E Seeley
{"title":"NECROHEMORRHAGIC MENINGOENCEPHALITIS IN A RED RUFFED LEMUR (<i>VARECIA RUBRA</i>) CAUSED BY <i>ACANTHAMOEBA</i> T1 GENOTYPE.","authors":"Hunter Ferchaw, Bayla Bessemer, Sasha Dixon, Rory C Chien, Jana M Ritter, Ibne Karim M Ali, Shantanu Roy, Kathryn E Seeley","doi":"10.1638/2025-0096","DOIUrl":null,"url":null,"abstract":"<p><p>A 5-yr-old castrated male red ruffed lemur (<i>Varecia rubra</i>) was evaluated for cluster seizures over a 24-h period. Seizures were refractory to anticonvulsive therapy. MRI revealed meningoencephalitis affecting the left occipital lobe. Because of concern for superrefractory status epilepticus and overall poor prognosis, the animal was humanely euthanized. Postmortem examination revealed necrohemorrhagic meningoencephalitis with intralesional amoebic trophozoites and cysts. The causative agent was identified as <i>Acanthamoeba</i> spp. T1 genotype via immunohistochemistry staining and species-specific real-time PCR. To the authors' knowledge, this is the first documented report of <i>Acanthamoeba</i> T1 genotype meningoencephalitis in a nonhuman primate in professional care.</p>","PeriodicalId":17667,"journal":{"name":"Journal of Zoo and Wildlife Medicine","volume":"57 1","pages":"113-118"},"PeriodicalIF":0.5000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Zoo and Wildlife Medicine","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1638/2025-0096","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
A 5-yr-old castrated male red ruffed lemur (Varecia rubra) was evaluated for cluster seizures over a 24-h period. Seizures were refractory to anticonvulsive therapy. MRI revealed meningoencephalitis affecting the left occipital lobe. Because of concern for superrefractory status epilepticus and overall poor prognosis, the animal was humanely euthanized. Postmortem examination revealed necrohemorrhagic meningoencephalitis with intralesional amoebic trophozoites and cysts. The causative agent was identified as Acanthamoeba spp. T1 genotype via immunohistochemistry staining and species-specific real-time PCR. To the authors' knowledge, this is the first documented report of Acanthamoeba T1 genotype meningoencephalitis in a nonhuman primate in professional care.
期刊介绍:
The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers.
The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution.
Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.