Lipocalin-2 and Bone Loss: A Brief Review.

IF 0.7 4区医学 Q4 ORTHOPEDICS

Acta orthopaedica Belgica Pub Date : 2025-12-01 DOI:10.52628/91.4.14943

M Mohammadi, A Jalali

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Abstract

Background: Recent research has redefined bone as an active endocrine organ with diverse physiological functions beyond structural support. Among the hormones secreted by osteoblasts, lipocalin 2 (LCN2) has gained attention for its dual roles in regulating bone metabolism and systemic energy balance.

Materials: A comprehensive review of the literature was conducted, focusing on experimental and clinical studies that investigate LCN2 secretion by osteoblasts, its impact on bone remodeling, and its systemic effects on appetite regulation and energy homeostasis.

Results: LCN2 acts as a context-dependent regulator of bone metabolism. Evidence indicates that it promotes bone formation under certain conditions while also stimulating bone resorption in others. Beyond the skeleton, LCN2 serves as a potent anorexigenic hormone, linking bone-derived signals to appetite control and systemic energy regulation.

Conclusion: LCN2 represents a key mediator at the intersection of skeletal health and systemic metabolism. Its dual effects on bone remodeling and its ability to regulate appetite highlight its potential as a therapeutic target for managing skeletal diseases and metabolic disorders.

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脂钙素-2与骨质流失：综述。

背景：近年来的研究将骨重新定义为一个活跃的内分泌器官，除了结构支持外，还具有多种生理功能。在成骨细胞分泌的激素中，脂载蛋白2 （lipocalin 2, LCN2）因其调节骨代谢和全身能量平衡的双重作用而受到关注。材料：我们对相关文献进行了全面的综述，重点研究了成骨细胞分泌LCN2、其对骨重塑的影响以及其对食欲调节和能量稳态的全身作用的实验和临床研究。结果：LCN2作为骨代谢的上下文依赖性调节因子。有证据表明，它在某些情况下促进骨形成，同时在其他情况下也刺激骨吸收。在骨骼之外，LCN2作为一种有效的厌食激素，将骨源性信号与食欲控制和全身能量调节联系起来。结论：LCN2是骨骼健康和全身代谢的关键中介。它对骨重塑的双重作用和调节食欲的能力突出了它作为治疗骨骼疾病和代谢紊乱的治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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