Zhongwei Zhang, Jun Liu, Wei Xue, Haoran Zhang, Mimi Wang, Qing-Jie Liu
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引用次数: 0
Abstract
Background: Radiation-induced intestinal injury (RIII) is a serious complication of radiotherapy and is closely associated with mitochondrial dysfunction, but the underlying mechanism remains unclear.
Methods: Mitochondria‑related differentially expressed genes (DEGs) were identified using online databases in an RIII model. Histopathological staining analysis was performed to evaluate injury severity. The expression of Mrm2 was examined in vivo after irradiation.
Results: The core functional modules of the identified DEGs included mitochondrial‑coding genes and apoptosis‑related genes. Histopathological analysis showed that RIII aggravated significantly in a dose‑ and time‑dependent manner. Notably, Mrm2 was continuously upregulated after irradiation in vivo.
Conclusion: Mrm2 may serve as a key regulatory factor mediating mitochondrial dysfunction in radiation‑induced intestinal injury.
期刊介绍：
The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source.
Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged:
• Biomarkers of disease
• Biomarkers of exposure
• Biomarkers of response
• Biomarkers of susceptibility
Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.
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