Hui Huang, Zhongda Liu, Xiaojing Liu, Quan Li, Xiaoming Yang, Lingyong Chen, Wenqian Ye
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引用次数: 0
Abstract
Objective: To present a case of a non-human immunodeficiency virus (HIV)-infected patient with human cytomegalovirus (HCMV) viremia and severe Pneumocystis jirovecii (PJ) pneumonia.
Case report: The patient was admitted in June 2024 for chronic dry cough and dyspnea. Sputum-targeted next-generation sequencing (tNGS) and blood pathogen metagenomic detection were used to identify concurrent infections of sputum HCMV and PJ, along with blood HCMV. The extensive treatment included intravenous ganciclovir, in conjunction with caspofungin and oral sulfamethoxazole, augmented by glucocorticoids and breathing assistance. After three weeks, the patient's oxygenation index markedly improved, accompanied by the significant resolution of imaging lesions, leading to patient discharge in June 2024.
Conclusion: This case underscores the diagnostic efficacy of tNGS on several opportunistic infections for older people with several comorbidities.
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