3D printed electrochemical origami-paper integrated cell chamber (EO-PICC) engineered with hierarchical nanocomposites for achieving unparalleled sensitivity in methamphetamine drug detection

IF 2.9 4区工程技术 Q2 INSTRUMENTS & INSTRUMENTATION

Microfluidics and Nanofluidics Pub Date : 2026-04-03 DOI:10.1007/s10404-026-02891-2

Nigar Anzar, Yashda Singh, Shariq Suleman, Jagriti Narang

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Abstract

A three-dimensional electrochemical origami-paper integrated cell chamber (3DP EO-PICC) that detects methamphetamine, an illicit drug, at a minimum concentration of 0.01 µg/mL is presented in this study. The sensor was made from an ecologically friendly polylactic acid (PLA) filament with a single foldable origami flap and a central reaction chamber for loading samples onto the paper printed electrode. The electrode acts as a reaction chamber where analyte interact with the pre-deposited zinc oxide & graphene oxide nanocomposite (ZnO-GO NCs), which is manufactured using a chemical reduction technique. Cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) were used for the detection of methamphetamine (Meth), proving the sensor’s excellent sensitivity. Integrating 3D printing with nano-biosensing devices allow accurate spatial positioning of nanoscale components, improves analyte interaction via greater surface area, and enables adjustable sensor designs. This technique facilitates the inclusion of complicated structures into sensor design while also enabling scalable, cost-effective manufacture, opening the way for creative and practical biosensing platforms.

Graphical abstract

查看原文本刊更多论文

3D打印电化学折纸集成细胞室（EO-PICC）采用分层纳米复合材料设计，在甲基苯丙胺药物检测中实现了无与伦比的灵敏度

本研究提出了一种三维电化学折纸集成细胞室（3DP EO-PICC），可以检测最低浓度为0.01 μ g/mL的非法药物甲基苯丙胺。该传感器由一种环保的聚乳酸（PLA）长丝制成，带有一个可折叠的折纸瓣和一个中央反应室，用于将样品装载到纸质印刷电极上。电极作为一个反应室，分析物与预沉积的氧化锌和氧化石墨烯纳米复合材料（ZnO-GO NCs）相互作用，这是使用化学还原技术制造的。采用循环伏安法（CV）、线性扫描伏安法（LSV）和电化学阻抗谱法（EIS）对甲基苯丙胺（Meth）进行检测，结果表明该传感器具有良好的灵敏度。将3D打印与纳米生物传感设备相结合，可以实现纳米级组件的精确空间定位，通过更大的表面积改善分析物的相互作用，并实现可调节的传感器设计。这项技术有助于将复杂的结构纳入传感器设计，同时也实现了可扩展的、具有成本效益的制造，为创新和实用的生物传感平台开辟了道路。图形抽象

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来源期刊

Microfluidics and Nanofluidics 工程技术-纳米科技

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

2 months

期刊介绍： Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).