{"title":"Epigallocatechin Gallate as an Anti-Fibrotic Agent","authors":"Yury S. Tarahovsky, Sergey G. Gaidin, Yury A. Kim","doi":"10.1134/S0006297925603715","DOIUrl":null,"url":null,"abstract":"<p>Epigallocatechin gallate (EGCG), a major polyphenolic compound in green tea, exhibits preventive and therapeutic effects in many fibrotic diseases. Tissue fibrosis is characterized by excessive deposition of collagen fibrils in the extracellular matrix, primarily due to dysregulation of cellular signaling pathways. However, we have previously demonstrated that EGCG directly inhibits the formation of collagen fibrils from collagen monomers under <i>in vitro</i> experimental conditions that excluded involvement of cellular signaling systems. This review explores the antifibrotic action of EGCG, which may occur through (i) its influence on cellular signaling and (ii) direct binding to collagen monomers, leading to the inhibition of pathological fibrillogenesis, as well as discuss the prospects for targeting the collagen assembly process.</p>","PeriodicalId":483,"journal":{"name":"Biochemistry (Moscow)","volume":"91 3","pages":"432 - 447"},"PeriodicalIF":2.1000,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow)","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1134/S0006297925603715","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Epigallocatechin gallate (EGCG), a major polyphenolic compound in green tea, exhibits preventive and therapeutic effects in many fibrotic diseases. Tissue fibrosis is characterized by excessive deposition of collagen fibrils in the extracellular matrix, primarily due to dysregulation of cellular signaling pathways. However, we have previously demonstrated that EGCG directly inhibits the formation of collagen fibrils from collagen monomers under in vitro experimental conditions that excluded involvement of cellular signaling systems. This review explores the antifibrotic action of EGCG, which may occur through (i) its influence on cellular signaling and (ii) direct binding to collagen monomers, leading to the inhibition of pathological fibrillogenesis, as well as discuss the prospects for targeting the collagen assembly process.
期刊介绍：
Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
