Antitumor Efficacy of Combined Use of Drugs Containing Noble Metals, Gold and Silver Polyacrylates and Cisplatin

Abstract

The possibility of combined use of compounds containing precious metals, gold, silver, and cisplatin polyacrylates in experimental animal tumor models has been investigated. An additive effect has been found upon combined use of cisplatin and aurumacryl (Acatol adenocarcinoma and Lewis lung carcinoma) and the therapeutic synergism of the combination of cisplatin with argacryl (Lewis lung carcinoma). A tumor that recurs after exposure to cisplatin retains the sensitivity inherent in the original tumor to both cisplatin and argacryl (Lewis lung carcinoma).