{"title":"[The Clinical Applicability of Blood Biomarkers for Alzheimer's disease in the Memory Clinic].","authors":"Marleen Kloppenburg-Lagendijk, Ymkje Huitema, Argonde van Harten, Liesbeth Hempenius, Nicolaas Verwey","doi":"10.54195/tgg24597","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The development of highly sensitive assays has enabled the detection of biomarkers of Alzheimer's disease in blood. In this literature review, we discuss their clinical applicability based on recent studies.</p><p><strong>Methods: </strong>A systematic search was conducted across Embase, Pubmed, Web of Science, Cochrane Central, and Google Scholar for studies published since 2021, using the search terms 'Alzheimer's Disease', 'Blood Biomarkers' and 'Memory Clinic'.</p><p><strong>Results: </strong>Based on the 11 included studies, pTau181, pTau217, NfL and GFAP appear to be clinically relevant (diagnostic value, AUC > 0.7) as blood biomarker.</p><p><strong>Conclusions: </strong>Multiple blood biomarkers appear to be clinically relevant for diagnostics in a memory clinic setting. However, this conclusion is based on just 11 studies, highlighting the need for further research in real-world populations within memory clinics.</p>","PeriodicalId":101340,"journal":{"name":"Tijdschrift voor gerontologie en geriatrie","volume":"57 1","pages":"10-27"},"PeriodicalIF":0.0000,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tijdschrift voor gerontologie en geriatrie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54195/tgg24597","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The development of highly sensitive assays has enabled the detection of biomarkers of Alzheimer's disease in blood. In this literature review, we discuss their clinical applicability based on recent studies.
Methods: A systematic search was conducted across Embase, Pubmed, Web of Science, Cochrane Central, and Google Scholar for studies published since 2021, using the search terms 'Alzheimer's Disease', 'Blood Biomarkers' and 'Memory Clinic'.
Results: Based on the 11 included studies, pTau181, pTau217, NfL and GFAP appear to be clinically relevant (diagnostic value, AUC > 0.7) as blood biomarker.
Conclusions: Multiple blood biomarkers appear to be clinically relevant for diagnostics in a memory clinic setting. However, this conclusion is based on just 11 studies, highlighting the need for further research in real-world populations within memory clinics.
背景：高灵敏度检测方法的发展使得检测血液中阿尔茨海默病的生物标志物成为可能。在这篇文献综述中，我们根据最近的研究来讨论它们的临床应用。方法：系统检索Embase、Pubmed、Web of Science、Cochrane Central和b谷歌Scholar自2021年以来发表的研究，检索词为“阿尔茨海默病”、“血液生物标志物”和“记忆诊所”。结果：根据纳入的11项研究，pTau181、pTau217、NfL和GFAP作为血液生物标志物具有临床相关性（诊断价值，AUC >.7）。结论：多种血液生物标志物似乎与记忆临床诊断相关。然而，这一结论仅基于11项研究，强调了在记忆诊所对现实世界人群进行进一步研究的必要性。
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