Peng Gao, Chunlei Li, Ran Liu, Wenming Chen, Guangyao Zhai
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引用次数: 0
Abstract
Coronary heart disease (CHD) significantly contributes to global mortality, particularly in frail populations. This study investigated how frailty affects the predictive capacity of the triglyceride-glucose (TyG) index for CHD.Analysis of 8,080 participants utilized the TyG Index (high ≥ 8.697) and Frailty Index (frail ≥ 0.21). Logistic regression and restricted cubic spline analyses assessed the relationships between TyG and CHD.In non-frail individuals, TyG independently predicted CHD (OR = 1.89, 95% CI: 1.42-2.51) with a near-linear relationship. In frail populations, TyG lost predictive independence and showed a U-shaped relationship. Frailty significantly moderated the TyG-CHD association (Pinteraction = 0.036).Frailty substantially influences the predictive value of TyG for CHD. While TyG reliably predicts CHD in non-frail individuals, its utility diminishes in frail populations, highlighting the importance of incorporating frailty in CHD risk assessments.
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