Endocervical gastric-type AIS: a rare histologic finding that further supports the hypothesis of a pyloric-type metaplastic origin

IF 3.8 2区医学 Q2 CELL BIOLOGY

Histopathology Pub Date : 2026-10-07 Epub Date: 2026-04-01 DOI:10.1111/his.70150

Michele Paudice, Veronica Parrella, Giulia Scaglione

{"title":"Endocervical gastric-type AIS: a rare histologic finding that further supports the hypothesis of a pyloric-type metaplastic origin","authors":"Michele Paudice, Veronica Parrella, Giulia Scaglione","doi":"10.1111/his.70150","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Background</h3>\n \n <p>Gastric-type adenocarcinoma in situ (gAIS) is a rare, HPV-independent precursor of cervical adenocarcinoma with incompletely defined histogenesis.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>To report a case of gAIS and its association with pyloric-type gastric metaplasia.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>A case of gAIS in a 70-year-old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Conization revealed atypical glandular epithelium. The lesion was CK7/CDX2 positive, with mutant-type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric-type gastric metaplasia was identified.</p>\n </section>\n \n <section>\n \n <h3> Discussion</h3>\n \n <p>The association with pyloric-type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This case supports a possible link between gAIS and pyloric-type gastric metaplasia, underscoring the importance of accurate recognition in HPV-independent cervical lesions.</p>\n </section>\n </div>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":"89 5","pages":"892-894"},"PeriodicalIF":3.8000,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.70150","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Histopathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/his.70150","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/4/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Gastric-type adenocarcinoma in situ (gAIS) is a rare, HPV-independent precursor of cervical adenocarcinoma with incompletely defined histogenesis.

Aims

To report a case of gAIS and its association with pyloric-type gastric metaplasia.

Materials and Methods

A case of gAIS in a 70-year-old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically.

Results

Conization revealed atypical glandular epithelium. The lesion was CK7/CDX2 positive, with mutant-type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric-type gastric metaplasia was identified.

Discussion

The association with pyloric-type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples.

Conclusion

This case supports a possible link between gAIS and pyloric-type gastric metaplasia, underscoring the importance of accurate recognition in HPV-independent cervical lesions.

查看原文本刊更多论文

宫颈内胃型AIS：一种罕见的组织学发现，进一步支持幽门型化生起源的假设。

背景：胃型原位腺癌（gAIS）是一种罕见的、不依赖hpv的宫颈腺癌前体，其组织发生不完全明确。目的：报告1例gAIS及其与幽门型胃化生的关系。材料和方法：对1例70岁女性非典型腺细胞（巴氏试验）和HPV分子检测阴性的gAIS进行组织学和免疫组织化学评价。结果：锥形显示非典型腺上皮。病变为CK7/CDX2阳性，p53突变型表达，CK20、PAX8、p16阴性。发现邻近幽门型胃化生。讨论：与幽门型化生的关联支持可能的化生起源，并在有限的样本中突出诊断挑战。结论：本病例支持gAIS与幽门型胃化生之间的可能联系，强调准确识别hpv非依赖性宫颈病变的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Histopathology 医学-病理学

CiteScore

10.20

自引率

4.70%

发文量

239

审稿时长

1 months

期刊介绍： Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.