{"title":"Antibacterial Wound Dressing Enables Reliable Detection of Uric Acid in Exudates","authors":"Bozhang Li, Mingrui Lv","doi":"10.1002/elan.70129","DOIUrl":null,"url":null,"abstract":"<p>Through the successful grafting of epoxypropyl dimethyl dodecyl ammonium chloride (EDDAC) onto bacterial cellulose (BC) and multiwalled carbon nanotube (CNT) surfaces, a novel and stable antibacterial wound dressing (BC-EDDAC-CNTs) was fabricated. Compared with bare BC membranes, BC-EDDAC exhibited significantly enhanced antibacterial activity. Furthermore, a nonenzymatic uric acid (UA) sensor was constructed on the membrane surface via the electrodeposition of AuNPs, resulting in an antibacterial wound dressing with integrated UA-sensing capability. In vitro evaluations further indicated high L929 cell viability (∼94%–95%), very low hemolysis (<0.5%), and effective bactericidal activity confirmed by Live/Dead staining. This multifunctional dressing enables simultaneous infection control and metabolic monitoring along a clinically relevant chronic wound management workflow, including passive exudate sampling, low-volume analysis, and real-time electrochemical readout.</p>","PeriodicalId":162,"journal":{"name":"Electroanalysis","volume":"38 3","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/elan.70129","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electroanalysis","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/elan.70129","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Through the successful grafting of epoxypropyl dimethyl dodecyl ammonium chloride (EDDAC) onto bacterial cellulose (BC) and multiwalled carbon nanotube (CNT) surfaces, a novel and stable antibacterial wound dressing (BC-EDDAC-CNTs) was fabricated. Compared with bare BC membranes, BC-EDDAC exhibited significantly enhanced antibacterial activity. Furthermore, a nonenzymatic uric acid (UA) sensor was constructed on the membrane surface via the electrodeposition of AuNPs, resulting in an antibacterial wound dressing with integrated UA-sensing capability. In vitro evaluations further indicated high L929 cell viability (∼94%–95%), very low hemolysis (<0.5%), and effective bactericidal activity confirmed by Live/Dead staining. This multifunctional dressing enables simultaneous infection control and metabolic monitoring along a clinically relevant chronic wound management workflow, including passive exudate sampling, low-volume analysis, and real-time electrochemical readout.
期刊介绍：
Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications.
Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.
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