Growth in Children with a Cleft Lip and/or Palate in 8 US Hospitals: A Retrospective Cohort Study.

IF 2 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

JDR Clinical & Translational Research Pub Date : 2026-10-01 Epub Date: 2026-03-31 DOI:10.1177/23800844261423910

C M McKinney, W Howard, K Bijlani, S Kinter, C Crerand, R Dang, O Jackson, C Discolo, M Rosenman, E Mendonca, I Ormanidou, K Dickinson, C L Heike

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引用次数: 0

Abstract

Objectives: To evaluate growth patterns in US children with cleft overall and by cleft lip (CL), CL and palate (CLP), and cleft palate (CP) across US children's hospitals from 0 to 18 mo of age.

Design: We conducted a retrospective cohort study leveraging medical records from 2009 to 2022 in children with a cleft seen at 8 US children's hospitals.

Participants: Individuals with a cleft seen at a PEDSnet consortium hospital.

Exposure: We examined growth over time, by cleft type, and across hospitals.

Main outcomes: We used electronic health data to generate weight-for-age z scores (WAZ) and length-for-age z scores (LAZ), as well as underweight (WAZ <-2) and stunting (LAZ <-2). We tracked longitudinal growth using generalized linear mixed models to estimate mean WAZ and LAZ from 0 to 18 mo of age. We compared the prevalence of underweight and stunting against World Health Organization growth standards.

Results: Our sample included 10,223 children: 19.1% with CL, 31.7% with CLP, and 49.2% with CP. WAZ and LAZ trajectories showed a fast rate of decline in the first 4 mo of life (P < 0.001). Between 6 and 12 mo and between 12 and 18 mo, WAZ showed a significant nonlinear increase in growth (P < 0.01) while LAZ remained unchanged (P > 0.05). All children had a higher prevalence of underweight and stunting relative to World Health Organization growth standards. Underweight and stunting were highest among those with CP, followed by CLP and then CL, and varied across hospitals.

Conclusions: Growth trajectories were slower in the first 4 mo of life, followed by rapid catch-up in weight to 12 mo of age. Children with cleft had a high prevalence of underweight and stunting at all ages. Variability across hospitals suggests that care patterns may affect growth. Close growth monitoring in the first 4 mo in children with cleft may be warranted.Knowledge Transfer Statement:US children with a cleft of the lip and/or palate have substantial growth deficits that vary by cleft type, comorbidities, and across hospitals, particularly in the first 4 mo of life.

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美国8家医院中唇腭裂患儿的生长情况：一项回顾性队列研究

目的：评估美国儿童医院中0 - 18月龄的整体唇裂、唇裂（CL）、唇裂和腭裂（CLP）和腭裂（CP）儿童的生长模式。设计：我们进行了一项回顾性队列研究，利用2009年至2022年在美国8家儿童医院就诊的唇腭裂儿童的医疗记录。参与者：在PEDSnet联合医院看到的唇裂患者。暴露：我们根据裂缝类型和不同医院的情况，研究了裂缝随时间的增长情况。结果：我们的样本包括10,223名儿童：19.1%患有CL， 31.7%患有CLP， 49.2%患有CP。WAZ和LAZ轨迹显示在生命的前4个月下降速度很快（P < 0.001）。6 ~ 12月和12 ~ 18月WAZ呈显著的非线性增长（P < 0.01）， LAZ基本不变（P < 0.05）。与世界卫生组织的生长标准相比，所有儿童体重不足和发育迟缓的发生率都较高。体重不足和发育迟缓在CP患者中最高，其次是CLP，然后是CL，各医院的情况有所不同。结论：婴儿出生后4个月的生长轨迹较慢，随后体重迅速回升至12个月。唇裂儿童体重不足和发育迟缓的发生率在各个年龄段都很高。医院之间的差异表明，护理模式可能会影响生长。在唇裂儿童的头4个月密切监测生长可能是有必要的。知识转移声明：美国唇裂和/或腭裂儿童有明显的生长缺陷，这种缺陷因唇裂类型、合并症和不同医院而异，特别是在出生后的头4个月。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JDR Clinical & Translational Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.20

自引率

6.70%

发文量

期刊介绍： JDR Clinical & Translational Research seeks to publish the highest quality research articles on clinical and translational research including all of the dental specialties and implantology. Examples include behavioral sciences, cariology, oral & pharyngeal cancer, disease diagnostics, evidence based health care delivery, human genetics, health services research, periodontal diseases, oral medicine, radiology, and pathology. The JDR Clinical & Translational Research expands on its research content by including high-impact health care and global oral health policy statements and systematic reviews of clinical concepts affecting clinical practice. Unique to the JDR Clinical & Translational Research are advances in clinical and translational medicine articles created to focus on research with an immediate potential to affect clinical therapy outcomes.