Establishing absolute and vitreous-normalized reference apparent diffusion coefficient values of the lacrimal gland in healthy individuals.

IF 2.7 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2026-07-01 Epub Date: 2026-03-31 DOI:10.1007/s10384-026-01352-1

Tahsin Aybal, Fatih Mehmet Tezcan

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引用次数: 0

Abstract

Purpose: To establish normative apparent diffusion coefficient (ADC) values of the lacrimal gland in a large cohort of healthy subjects and to compare the results with previously reported data.

Study design: Retrospective cohort study.

Methods: Brain magnetic resonance (MR) images of 260 healthy individuals were retrospectively analyzed. ADC measurements were performed bilaterally using a standardized region of interest (ROI) technique. The values were compared according to age and sex. To ensure normalization and standardization, vitreous ADC measurements were performed using the same ROI used for lacrimal gland measurements. Lacrimal gland ADC values were divided by vitreous ADC values.

Results: The lacrimal gland ADCmean value was 1.29 ± 0.14 ×10⁻³ mm²/s. No significant difference was observed in terms of ADC measurements between the right and left glands (p > 0.05). Sex had no statistically significant effect on ADC values (p > 0.05). The mean vitreous ADC value was 3.08 ± 0.20 ×10⁻³ mm²/s. The lacrimal gland/vitreous ADCmean ratio was 0.42 ± 0.05. Correlation analysis revealed weak positive correlations between age and lacrimal gland ADCmean (r = 0.185, p = 0.003) and ADCmax (r = 0.260, p < 0.001).

Conclusion: This study presents a large series on normative ADC values of the lacrimal gland in healthy individuals. The results provide reliable reference data that may assist in the differential diagnosis of inflammatory and neoplastic pathologies.

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建立健康人泪腺绝对和玻璃体归一化表观扩散系数参考值。

目的：建立大量健康受试者泪腺表观弥散系数（ADC）的规范值，并与以往报道的数据进行比较。研究设计：回顾性队列研究。方法：对260例正常人的脑磁共振图像进行回顾性分析。ADC测量采用标准化感兴趣区域（ROI）技术进行双边测量。根据年龄和性别对这些数值进行比较。为了确保标准化和标准化，玻璃体ADC测量使用与泪腺测量相同的ROI进行。泪腺ADC值除以玻璃体ADC值。结果：泪腺adc平均值为1.29±0.14 ×10⁻3 mm2/s。左、右腺体ADC值差异无统计学意义（p < 0.05）。性别对ADC值的影响无统计学意义（p < 0.05）。平均玻璃体ADC值为3.08±0.20 ×10⁻3 mm2/s。泪腺/玻璃体平均比值为0.42±0.05。相关分析显示，年龄与泪腺ADCmean （r = 0.185, p = 0.003）、ADCmax （r = 0.260, p < 0.001）呈弱正相关。结论：本研究提供了健康人群泪腺正常ADC值的一个大系列。结果提供了可靠的参考数据，可能有助于炎性和肿瘤病理的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.