Rh-Catalyzed [4+2+1] Cycloaddition Reactions of Ene-Allenes with Alkynes/Allenes/Alkenes and CO

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2026-03-07 DOI:10.1002/ajoc.70295

Liang Dang, Ling-Ling Ma, Zhi-Xiang Yu

引用次数: 0

Abstract

In this study, the reaction scopes of [4+2+1] cycloaddition between ene-allenes (from acyloxy-enynes) with alkynes/allenes/alkenes and CO have been studied, revealing that reaching 5/7 skeletons by these reactions can be realized with high confidence. To reach 6/7 skeletons, the C₂ components can only be alkynes and allenes. High diastereo-selectivities can be achieved for the [4+2+1] reactions for substrates with a substituent in their tethers. Ene-allenes can also be used directly as the C₄ synthons in the [4+2+1] reactions.

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铑催化烯-烯与炔/烯/烯和一氧化碳的[4+2+1]环加成反应

本研究研究了烯-烯（由氧基烯）与炔/烯/烯烃和CO之间的[4+2+1]环加成反应的反应范围，表明这些反应可以高可信度地达到5/7个骨架。要达到6/7骨架，C2组分只能是炔和烯。对于系链中含有取代基的底物，[4+2+1]反应具有较高的非立体选择性。烯-烯也可以在[4+2+1]反应中直接用作C4合成子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.