Cascade Construction of Diverse Thiazoloindoles via the Generation of New Indole Skeletons Under Microwave Irradiation

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2026-03-04 DOI:10.1002/ajoc.70361

Jiahong Wang, Guanghua Wei, Hao Shen, Chunmei Li, Furen Zhang

引用次数: 0

Abstract

A highly efficient method has been developed for synthesizing various substituted 2-methyl-7-aryl-6H-thiazoloindole derivatives through a microwave-assisted cascade process involving 2-methylbenzo[d]thiazol-5-amine or 2-methylbenzo[d]thiazol-6-amine, 2,2-dihydroxy-1-arylethan-1-one, and 1,3-dicarbonyl compounds or their analogs. Notably, this three-component transformation offers several advantages, including short reaction times, wide substrate tolerance, and the absence of harmful byproducts, delivering the target compounds in moderate to good yields.

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微波辐射下噻唑吲哚骨架的级联构建

建立了一种微波辅助级联合成各种取代的2-甲基-7-芳基-6-噻唑吲哚衍生物的高效方法，包括2-甲基苯并[d]噻唑-5-胺或2-甲基苯并[d]噻唑-6-胺、2,2-二羟基-1-芳基比1- 1和1,3-二羰基化合物或它们的类似物。值得注意的是，这种三组分转化具有几个优点，包括反应时间短，底物耐受性广，没有有害副产物，以中等到良好的收率提供目标化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.