Yibo Zong, Guo Long, Tiantian Gu, Pan Huang, Yong Tian, Wenwu Xu, Xiheng Hu, Dazun Shi, Lizhi Lu, Tao Zeng
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引用次数: 0
Abstract
Schematic representation showing that 20 (S)-Rg3 improves mouse NASH. 20(S)-Rg3 reduces OxPLs levels and ameliorates ferroptosis in the liver of NASH mice. Mechanistically, 20(S)-Rg3 activates SPOP. Meanwhile, SPOP attenuates the ATF3-mediated transcriptional repression of NUPR1 by enhancing the K48-linked ubiquitination of ATF3. Upregulated NUPR1 rescues redox balance and reduces lipid peroxidation, ultimately inhibiting hepatocellular ferroptosis.
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