A multicenter study by the Brazilian Society of Dermatology on a new standard patch test series

IF 4.4 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia Pub Date : 2026-03-01 Epub Date: 2026-03-27 DOI:10.1016/j.abd.2026.501327

Renan Rangel Bonamigo , Vanessa Barreto Rocha , Vitor Manoel Silva dos Reis , Dulcilea Ferraz Rodrigues , Rosana Lazzarini , Mario Cezar Pires , Renato Shintani Hikawa , Ana Elisa Kiszewski , Andrea Fernandes Eloy da Costa França , Renata Heck , Maria Antonieta Rios Scherrer , Luciana Paula Samorano , Isabella Campos Machado Cordeiro , Ida Alzira Duarte , Mariana de Figueiredo Silva Hafner , Renata Marli Gonçalves Pires , Lilith Sodré Eller , Juliana Barros Rodrigues , Daniela Benzano Bumaguin , Ruppert Ludwig Hahnstadt

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引用次数: 0

Abstract

Background

The prevalence of allergic contact dermatitis (ACD) differs across various populations, and the sensitization rate can change constantly as new products are introduced to the market. The current Brazilian standard series of patch tests has been used for over two decades. Therefore, the development of a new Brazilian standard series is important to ensure that contact tests remain a reliable diagnostic tool.

Methods

A Brazilian multicenter, cross-sectional, prospective study was conducted using a modified series of patch tests between 2023 and 2025. The factors under study were the substances used in the contact tests, and the outcomes were the frequencies of positivity and relevance. Demographic and clinical variables of the participants, who had contact dermatitis without a defined etiology prior to the tests, were evaluated. The required sample size was defined as 523 patients, estimating the prevalence of positivity with a 1.8% confidence interval. Wald's test was considered a 95% confidence level and a 1% expected prevalence of positivity.

Results

A total of 567 participants were included, 77.3% female, with a mean age of 53.3 years, and most belonged to phototypes II, III, and IV. Cleaning services were the most frequent occupational activity, and 43.3% of patients had a personal history of atopy. The overall reactivity of the tests was 69.3%, with 70.2% relevance. Nickel sulfate was the most frequently reactive allergen (28.9%), and 29 substances reached at least 1% positivity.

Limitations

Lack of representatives from all regions of Brazil and absence of prospective follow-up.

Conclusion

The authors propose a new Brazilian standard series of patch tests, with 40 substances, considering the 29 that achieved 1% positivity and another 11 with clinical importance and supported by current literature as emerging and current allergens.

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一项由巴西皮肤学会对新标准斑贴试验系列进行的多中心研究

背景：过敏性接触性皮炎（ACD）的患病率在不同人群中有所不同，并且随着新产品进入市场，致敏率会不断变化。目前的巴西标准系列斑贴试验已经使用了二十多年。因此，制定新的巴西标准系列对于确保接触试验仍然是可靠的诊断工具非常重要。方法在巴西进行一项多中心、横断面、前瞻性研究，在2023年至2025年期间采用一系列改进的斑贴试验。研究的因素是接触试验中使用的物质，结果是阳性和相关性的频率。在测试前没有明确病因的接触性皮炎患者的人口学和临床变量被评估。所需样本量定义为523例患者，以1.8%的置信区间估计阳性患病率。Wald的检验被认为是95%的置信水平和1%的阳性预期患病率。结果共纳入567例患者，女性77.3%，平均年龄53.3岁，多为光型II、III、IV型。清洁服务是最常见的职业，43.3%的患者有特应性病史。总体反应性为69.3%，相关性为70.2%。硫酸镍是最常见的反应性过敏原（28.9%），其中29种物质的阳性率达到1%以上。局限性：缺少来自巴西所有地区的代表，缺乏预期的后续行动。结论作者提出了一个新的巴西标准系列的贴片试验，包括40种物质，考虑到29种达到1%的阳性，另外11种具有临床重要性并得到当前文献支持的新出现和当前的过敏原。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anais brasileiros de dermatologia DERMATOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

184

审稿时长

32 days

期刊介绍： The journal is published bimonthly and is devoted to the dissemination of original, unpublished technical-scientific study, resulting from research or reviews of dermatological topics and related matters. Exchanges with other publications may be accepted.