CENTENARIAN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-08-01 DOI:10.1097/IAE.0000000000004837

Vittorio Capuano, Serena Fragiotta, Jeremy Abadou, Riccardo Sacconi, Alexandra Miere, Francesca Amoroso, Eric H Souied, Giuseppe Querques

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引用次数: 0

Abstract

Purpose: To report clinical characteristics of exudative neovascular age-related macular degeneration in centenarian patients.

Methods: A retrospective, longitudinal study conducted in two retinal referral centers in Europe. Clinical characteristics of patients with neovascular age-related macular degeneration having at last follow-up at least 100 years and older were reviewed.

Results: Twenty-eight eyes from 14 patients (13 women), with a mean baseline age of 95.7 (SD 4.1) years and a mean follow-up duration of 89 months (39.9). The mean age at the last follow-up was 102.4 (1.7) years. Most eyes (86%) presented Type 1 macular neovascularization. At the last follow-up, best-corrected visual acuity was stable or improved in 57% of eyes, with a mean final best-corrected visual acuity of 53 letters (21.8), Snellen equivalent 20/100. Eyes with better visual outcomes (>50 letters) had significantly higher baseline best-corrected visual acuity ( P < 0.001) and thicker subfoveal choroidal thickness ( P = 0.03). Macular hemorrhage (25%) and macular atrophy (53.6%) were associated with poorer best-corrected visual acuity.

Conclusion: Centenarian patients with neovascular age-related macular degeneration can maintain vision with long-term anti-VEGF therapy. These findings underscore the need for tailored management strategies for the challenges faced by centenarians with neovascular age-related macular degeneration.

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新生血管性老年性黄斑变性的百岁患者。

目的：报道百岁老人渗出性新生血管性黄斑变性（AMD）的临床特点。方法：在欧洲的两个视网膜转诊中心进行回顾性、纵向研究。回顾了随访≥100年的新生血管性AMD患者的临床特征。结果：14例患者28只眼（女性13例），平均基线年龄95.7岁（SD 4.1），平均随访89个月（39.9）。最后一次随访的平均年龄为102.4（1.7）岁。多数（86%）为1型黄斑新生血管（MNV）。在最后一次随访中，57%的眼睛的最佳矫正视力（BCVA）稳定或改善，平均最终BCVA为53个字母（21.8）Snellen等效20/100。视力结果较好的眼睛（bbb50字母）的BCVA基线值明显较高(p结论：百岁新生血管性AMD患者可以通过长期抗vegf治疗维持视力。这些发现强调了针对新血管性AMD的百岁老人所面临的挑战制定量身定制的管理策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.