Sex-related differences in psoriatic arthritis (PsA) treatment outcomes

IF 7 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-09-01 Epub Date: 2026-03-25 DOI:10.1016/j.berh.2026.102132

Alicia Tran, Lihi Eder

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引用次数: 0

Abstract

Sex-related differences are evident across multiple domains of psoriatic arthritis (PsA), including clinical presentation and treatment response. Across biologic and targeted therapies, female patients with PsA consistently demonstrate lower response and more frequent treatment discontinuation compared with males. However, mechanisms underlying sex-based differences in treatment response remain unclear. This gap is further limited by the underreporting of sex-disaggregated outcomes in clinical trials and observational studies. This review synthesizes current evidence on sex differences in treatment efficacy and drug persistence in PsA, with attention to variation across therapeutic drug classes. Potential mechanisms contributing to differential treatment response are explored, including differences in disease characteristics, comorbidities, pain perception, adiposity, pharmacokinetics, immune and inflammatory factors, and gender-related sociocultural factors. Understanding these disparities is essential to inform personalized treatment strategies and guide future sex-informed research in PsA.

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银屑病关节炎（PsA）治疗结果的性别相关差异

性别相关的差异在银屑病关节炎（PsA）的多个领域是明显的，包括临床表现和治疗反应。在生物和靶向治疗中，与男性相比，女性PsA患者始终表现出较低的反应和更频繁的停药。然而，基于性别的治疗反应差异的机制仍不清楚。临床试验和观察性研究中按性别分类的结果报告不足进一步限制了这一差距。这篇综述综合了目前关于PsA治疗疗效和药物持久性的性别差异的证据，并关注了不同治疗药物类别的差异。本文探讨了导致不同治疗反应的潜在机制，包括疾病特征、合并症、疼痛感知、肥胖、药代动力学、免疫和炎症因素以及与性别相关的社会文化因素的差异。了解这些差异对于个性化治疗策略和指导未来PsA的性别信息研究至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.