Salivary insulin-like growth factor-1 (IGF-1) and bone alkaline phosphatase (BALP) levels during mandibular advancement with Twin Block appliance: A longitudinal study.

IF 1.5 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Orthodontics Pub Date : 2026-03-25 DOI:10.1177/14653125261427467

Tulika Tripathi, Navneet Singh, Veena Gv, Rinkle Sardana, Bhawna Mahajan, Priyank Rai

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引用次数: 0

Abstract

Objective: To assess salivary insulin-like growth factor-1 (IGF-1) and bone alkaline phosphatase (BALP) levels during mandibular advancement with Twin Block appliance.

Methods: The study enrolled 49 participants with skeletal Class 2 malocclusion, a retrognathic mandible, positive visual treatment objective (VTO), horizontal to average growth pattern and cervical vertebrae maturation index stages 3-4 (CVMI). Participants were treated with Twin Block appliance (Twin Block group [TBG]; n = 39). Salivary samples were collected before treatment (T0), at 7-10 days (T1), 6-10 weeks (T2), 8-10 months (T3) and after treatment (T4). Non-compliant participants formed the non-compliant group (NCG; n = 10). Lateral cephalograms were obtained for cephalometric evaluation. Statistical analyses compared salivary IGF-1 and BALP levels and cephalometric parameters within and between groups.

Results: The final sample included 39 participants in the TBG (17 boys, 22 girls; mean age =12.56 ± 1.09 years) and 10 participants in the NCG (5 boys, 5 girls; mean age =12.7 ± 1.16 years). A significant difference was observed in the salivary IGF-1 and BALP levels within the TBG across different time intervals. In the TBG, IGF-1 increased significantly at T1, and BALP significantly increased at T2 and T3. The NCG showed no significant changes in levels of IGF and BALP. A significant positive correlation between IGF-1 and BALP was noted at T1 in the TBG (P <0.05), whereas a significant negative correlation was observed at T2 and T3 (P <0.05). Mann-Whitney test showed a significant increase in mandibular length in TBG compared to NCG. Cephalometric analysis revealed significant improvements in mandibular length in TBG compared to NCG between T0 and T4.

Conclusions: The study demonstrated a significant increase in salivary IGF-1 levels within 7-10 days, with BALP levels peaking at 6-10 weeks. These findings suggest a potential role of IGF-1 and BALP in the biochemical response to Twin Block appliance therapy.

查看原文本刊更多论文

唾液胰岛素样生长因子-1 （IGF-1）和骨碱性磷酸酶（BALP）水平在下颌推进双块矫形器：一项纵向研究。

目的：评价双块矫形器下颌前移过程中唾液胰岛素样生长因子-1 （IGF-1）和骨碱性磷酸酶（BALP）水平。方法：该研究招募了49名骨骼2类错颌，下颌后突，阳性视觉治疗目标（VTO），水平至平均生长模式和颈椎成熟指数阶段3-4 （CVMI）的参与者。参与者使用Twin Block矫治器（Twin Block组[TBG]； n = 39）。分别于治疗前（T0）、7-10天（T1）、6-10周（T2）、8-10个月（T3）和治疗后（T4）采集唾液样本。非服从组为非服从组（NCG, n = 10）。获得侧位头颅图用于头颅测量评估。统计学分析比较各组内和组间唾液IGF-1和BALP水平及头侧测量参数。结果：最终纳入TBG 39例（男17例，女22例，平均年龄12.56±1.09岁），NCG 10例（男5例，女5例，平均年龄12.7±1.16岁）。在不同的时间间隔内，观察到TBG内唾液IGF-1和BALP水平有显著差异。在TBG中，IGF-1在T1时显著升高，BALP在T2和T3时显著升高。NCG组IGF和BALP水平无明显变化。结论：研究表明，在7-10天内，唾液IGF-1水平显著升高，BALP水平在6-10周达到峰值。这些发现提示IGF-1和BALP在Twin Block器械治疗的生化反应中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orthodontics DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.60

自引率

15.40%

发文量

期刊介绍： The Journal of Orthodontics has an international circulation, publishing papers from throughout the world. The official journal of the British Orthodontic Society, it aims to publish high quality, evidence-based, clinically orientated or clinically relevant original research papers that will underpin evidence based orthodontic care. It particularly welcomes reports on prospective research into different treatment methods and techniques but also systematic reviews, meta-analyses and studies which will stimulate interest in new developments. Regular features include original papers on clinically relevant topics, clinical case reports, reviews of the orthodontic literature, editorials, book reviews, correspondence and other features of interest to the orthodontic community. The Journal is published in full colour throughout.