Clinical and Metabolic Characteristics of Spontaneous Remission in Type 2 Diabetes: A Real-World Study from South India.

IF 4.2 3区医学 Q2 Medicine

Diabetes Therapy Pub Date : 2026-05-01 Epub Date: 2026-03-24 DOI:10.1007/s13300-026-01858-4

Saravanan Jebarani, Bhavadharini Balaji, Viswanathan Baskar, Raghavan Bhuvaneswari, Coimbatore Subramanian Shanthi Rani, AnandaPerumal Lavonya, Sadasivam Ganesan, Ananthakrishnan Subramanian Akshay, Manodip Acharyya, Phillips Routray, Ranjit Unnikrishnan, Viswanathan Mohan, Ranjit Mohan Anjana

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Abstract

Introduction: This study aimed to evaluate clinical characteristics and outcomes of individuals with type 2 diabetes (T2D) who achieved spontaneous remission without structured intervention.

Methods: We examined electronic medical records of 243,400 adults with T2D attending a tertiary care center in India between 1993 and 2018. Spontaneous remission was defined as achieving glycated hemoglobin (HbA1c) < 6.5% for at least 3 months without glucose-lowering medication in those who earlier had HbA1c ≥ 6.5%. A matched group without remission was selected for comparison.

Results: Among 243,400 individuals with T2D, 275 (0.11%) achieved spontaneous remission. Remission occurred in 0.34% of individuals with baseline HbA1c < 7.0%, 0.13% with HbA1c 7.0-7.9%, and 0.08% with HbA1c ≥ 8.0%. Diabetes recurred in 69%, 80%, and 87% of these respective groups, after a median remission duration of 2.1 years. Sustained remission was observed in 55 individuals (0.02%). Individuals who achieved remission were older, had lower body weight and glucose levels, shorter duration, higher C-peptide, and greater physical activity. Relapse was associated with higher body weight and postprandial glucose levels. Individuals who had longer remission had greater weight loss.

Conclusion: Spontaneous remission of T2D is rare and mostly transient. Higher baseline HbA1c predicts relapse, while sustained weight loss is strongly associated with long-term remission.

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2型糖尿病自发缓解的临床和代谢特征：来自南印度的真实世界研究

本研究旨在评估2型糖尿病（T2D）患者在没有结构化干预的情况下实现自发缓解的临床特征和结局。方法：我们检查了1993年至2018年期间在印度三级医疗中心就诊的243,400名成年T2D患者的电子病历。自发缓解被定义为达到糖化血红蛋白（HbA1c）。结果：在243,400例T2D患者中，275例（0.11%）达到自发缓解。结论：T2D的自发缓解是罕见的，而且大多是短暂的。较高的基线HbA1c预示复发，而持续的体重减轻与长期缓解密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.