Prevalence, Incidence, and Associated Factors of Possible Sarcopenia in Patients Undergoing Maintenance Hemodialysis: A Prospective Cohort Study

IF 4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition Pub Date : 2026-07-01 Epub Date: 2026-03-19 DOI:10.1053/j.jrn.2026.03.004

Luchen He MD, Yujuan Zheng MD, Liyang Chang MD

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引用次数: 0

Abstract

Objectives

Possible sarcopenia refers to low muscle strength with or without reduced physical performance and is considered a sentinel stage of sarcopenia. Few studies have focused on possible sarcopenia in patients undergoing maintenance hemodialysis (MHD). Therefore, this study investigated the prevalence and incidence of possible sarcopenia in patients undergoing MHD and analyzed its associated factors to provide evidence for early identification and intervention in the prevention of sarcopenia.

Methods

This prospective cohort study collected demographic and laboratory parameters, dietary and nutritional status, and physical activity level (PAL) at baseline and 1-year follow-up. Possible sarcopenia was diagnosed based on the Asian Working Group for Sarcopenia 2019 Consensus, with assessments conducted at baseline and 1 year later. A binary logistic regression model was used to identify independent factors associated with the incidence of possible sarcopenia.

Results

In total, 346 patients undergoing MHD were included, of whom 293 completed the 1-year follow-up (women, 39.5%; mean age, 53.57 ± 12.43 years). The prevalence of possible sarcopenia at baseline was 50.0% (173 of 346), and the incidence after 1 year was 29.1% (43 of 148). Binary logistic regression analysis showed that possible sarcopenia was independently associated with age (OR = 1.071; 95% confidence interval [CI] = 1.023-1.122; P = .004), Modified Quantitative Subjective Global Assessment score (OR = 1.336; 95% CI = 1.020-1.749; P = .035), PAL (OR = 0.208; 95% CI = 0.071-0.605; P = .004), and phase angle (OR = 0.432; 95% CI = 0.241-0.775; P = .005).

Conclusions

The prevalence and incidence of possible sarcopenia are high among patients undergoing MHD. Older age, higher Modified Quantitative Subjective Global Assessment score, lower PAL, and lower phase angle were associated with an increased risk of possible sarcopenia.

查看原文本刊更多论文

维持性血液透析患者肌肉减少症的患病率、发病率和相关因素：一项前瞻性队列研究。

背景：可能的肌少症是指伴有或不伴有运动能力下降的肌肉力量低下，被认为是肌少症的前哨期。很少有研究关注维持性血液透析（MHD）患者可能出现的肌肉减少症。因此，本研究调查MHD患者可能发生的肌少症的患病率和发病率，并分析其相关因素，为早期识别和干预预防肌少症提供依据。方法：这项前瞻性队列研究收集了基线和1年随访时的人口统计学和实验室参数、饮食和营养状况以及身体活动水平（PAL）。根据亚洲肌少症工作组2019年共识诊断可能的肌少症，并在基线和1年后进行评估。采用二元logistic回归模型确定与可能的肌少症发生率相关的独立因素。结果：共纳入346例MHD患者，其中293例完成1年随访，女性占39.5%，平均年龄53.57±12.43岁。基线时可能的肌少症患病率为50.0%(173/346)，1年后的发病率为29.1%（43/148）。二元logistic回归分析显示，可能的肌少症与年龄（OR = 1.071, 95% CI = 1.023-1.122, P = 0.004）、修正定量主观整体评价（MQSGA）评分（OR = 1.336, 95% CI = 1.020-1.749, P = 0.035）、PAL （OR = 0.208, 95% CI = 0.071-0.605, P = 0.004）、相位角（PhA）（OR = 0.432, 95% CI = 0.247 -0.775, P = 0.005）独立相关。结论：MHD患者中可能发生的肌肉减少症的患病率和发生率较高。年龄越大、MQSGA评分越高、PAL越低、PhA越低与肌少症发生风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Nutrition 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

12.50%

发文量

146

审稿时长

6.7 weeks

期刊介绍： The Journal of Renal Nutrition is devoted exclusively to renal nutrition science and renal dietetics. Its content is appropriate for nutritionists, physicians and researchers working in nephrology. Each issue contains a state-of-the-art review, original research, articles on the clinical management and education of patients, a current literature review, and nutritional analysis of food products that have clinical relevance.