TRIM44 as a Multifunctional Regulator in Cancer and Non-Cancer Diseases: From Oncogenic Driver to Immune and Stress Response Modulator.

IF 2.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Protein and Peptide Letters Pub Date : 2026-01-01 DOI:10.2174/0109298665428424251216064630

Guive Sharifi, Tohid Emami Meybodi, Fatemeh Jayervand, Mahmood Emami Meybodi, Khatere Mokhtari, Parnaz Mohseni, Hanie Mahaki, Hamidreza Hasanzadeh, Elham Bateni, Yaser Sharafi, Farzan Fahim, Ahmad Hemmatyar, Esmaeil Mohammadi, Maryam Ahmadi, Majid Jahanshahi, Hamid Tanzadehpanah

{"title":"TRIM44 as a Multifunctional Regulator in Cancer and Non-Cancer Diseases: From Oncogenic Driver to Immune and Stress Response Modulator.","authors":"Guive Sharifi, Tohid Emami Meybodi, Fatemeh Jayervand, Mahmood Emami Meybodi, Khatere Mokhtari, Parnaz Mohseni, Hanie Mahaki, Hamidreza Hasanzadeh, Elham Bateni, Yaser Sharafi, Farzan Fahim, Ahmad Hemmatyar, Esmaeil Mohammadi, Maryam Ahmadi, Majid Jahanshahi, Hamid Tanzadehpanah","doi":"10.2174/0109298665428424251216064630","DOIUrl":null,"url":null,"abstract":"<p><p>Tripartite motif-containing protein 44 (TRIM44), a unique member of the TRIM family that lacks the canonical RING domain, has recently attracted significant attention for its broad oncogenic potential across diverse malignancies. Accumulating evidence indicates that TRIM44 is markedly overexpressed in cancers, including colorectal, gastric, lung, breast, ovarian, and prostate carcinomas, as well as glioblastoma, multiple myeloma, and hepatocellular carcinoma. Mechanistically, TRIM44 drives tumor progression by modulating critical signaling pathways, including PI3K/AKT/mTOR, NF-κB, Wnt/β-catenin, and epithelial-mesenchymal transition (EMT), primarily through stabilizing regulatory proteins or participating in non-coding RNA- mediated networks. In addition to its role in cancer, TRIM44 has been implicated in cardiovascular dysfunction, ischemia-reperfusion injury, diabetic complications, and neuroinflammation, underscoring its biological versatility. This review provides an overview of current evidence regarding the multifaceted roles of TRIM44 in both oncogenic and non-oncogenic diseases. By integrating insights from oncology, cardiology, neurology, and metabolic research, this review offers a unified perspective on TRIM44 as a pivotal molecular hub and an emerging diagnostic and therapeutic target.</p>","PeriodicalId":20736,"journal":{"name":"Protein and Peptide Letters","volume":" ","pages":"79-97"},"PeriodicalIF":2.5000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Protein and Peptide Letters","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2174/0109298665428424251216064630","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Tripartite motif-containing protein 44 (TRIM44), a unique member of the TRIM family that lacks the canonical RING domain, has recently attracted significant attention for its broad oncogenic potential across diverse malignancies. Accumulating evidence indicates that TRIM44 is markedly overexpressed in cancers, including colorectal, gastric, lung, breast, ovarian, and prostate carcinomas, as well as glioblastoma, multiple myeloma, and hepatocellular carcinoma. Mechanistically, TRIM44 drives tumor progression by modulating critical signaling pathways, including PI3K/AKT/mTOR, NF-κB, Wnt/β-catenin, and epithelial-mesenchymal transition (EMT), primarily through stabilizing regulatory proteins or participating in non-coding RNA- mediated networks. In addition to its role in cancer, TRIM44 has been implicated in cardiovascular dysfunction, ischemia-reperfusion injury, diabetic complications, and neuroinflammation, underscoring its biological versatility. This review provides an overview of current evidence regarding the multifaceted roles of TRIM44 in both oncogenic and non-oncogenic diseases. By integrating insights from oncology, cardiology, neurology, and metabolic research, this review offers a unified perspective on TRIM44 as a pivotal molecular hub and an emerging diagnostic and therapeutic target.

查看原文本刊更多论文

TRIM44作为癌症和非癌症疾病的多功能调节剂：从致癌驱动到免疫和应激反应调节剂。

Tripartite motif-containing protein 44 （TRIM44）是TRIM家族中缺乏典型RING结构域的独特成员，近年来因其在多种恶性肿瘤中的广泛致癌潜力而引起了人们的极大关注。越来越多的证据表明，TRIM44在癌症中明显过表达，包括结直肠癌、胃癌、肺癌、乳腺癌、卵巢癌和前列腺癌，以及胶质母细胞瘤、多发性骨髓瘤和肝细胞癌。从机制上讲，TRIM44主要通过稳定调节蛋白或参与非编码RNA介导的网络，通过调节关键信号通路（包括PI3K/AKT/mTOR、NF-κ b、Wnt/β-catenin和上皮-间质转化（EMT））来驱动肿瘤进展。除了在癌症中发挥作用外，TRIM44还与心血管功能障碍、缺血再灌注损伤、糖尿病并发症和神经炎症有关，强调了其生物学上的多功能性。这篇综述概述了目前关于TRIM44在致癌和非致癌疾病中的多方面作用的证据。通过整合肿瘤学、心脏病学、神经学和代谢研究的见解，本综述提供了关于TRIM44作为关键分子枢纽和新兴诊断和治疗靶点的统一观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis