AMPK as a regulatory node in cell death

IF 14.4 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2026-06-01 Epub Date: 2026-03-20 DOI:10.1016/j.tibs.2026.02.006

Dade Rong (容达德) , Shuai You (尤帅) , Han-Ming Shen (沈汉明)

引用次数: 0

Abstract

Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) is a critical kinase in the control of cellular metabolism, and in recent years, accumulating evidence has demonstrated that AMPK plays a critical role in the regulation of various types of regulated cell death (RCD) pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis. In this review, we will first discuss the regulatory roles of AMPK in these forms of RCD. Then, we will examine the implications of AMPK in diseases such as cancer, diabetes complications, ischemia–reperfusion injury, and infectious diseases, focusing on the therapeutic potential of AMPK activators and inhibitors through the regulation of different types of RCD.

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AMPK作为细胞死亡的调控节点。

腺苷单磷酸腺苷（AMP）活化蛋白激酶（AMPK）是控制细胞代谢的关键激酶，近年来越来越多的证据表明AMPK在多种类型的调节细胞死亡（RCD）途径中发挥关键作用，包括凋亡、坏死坏死、焦亡和铁亡。在这篇综述中，我们将首先讨论AMPK在这些形式的RCD中的调节作用。然后，我们将研究AMPK在癌症、糖尿病并发症、缺血再灌注损伤和传染病等疾病中的意义，重点关注AMPK激活剂和抑制剂通过调节不同类型的RCD的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.