An effective dihydroxanthene-based fluorescent probe for phosgene visual detection in solution and gaseous phases.

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2026-08-01 Epub Date: 2026-03-18 DOI:10.1016/j.talanta.2026.129685

Qinqin Tian, Zeyu Song, Wei He

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引用次数: 0

Abstract

Real-time monitoring of phosgene is of great significance for public health and environmental safety. To achieve this goal, a strategy was proposed to construct a probe structure featuring long excitation/emission wavelengths and high fluorescence quantum yield by introducing receptors with different electron-withdrawing abilities to regulate intramolecular charge transfer (ICT). Based on this, a class of fluorescent probes based on dihydroxanthene dyes (DHX-Phos-Pyr (Q.Y. = 7.91%), DHX-Phos-BZT (Q.Y. = 4.70%)) were designed and synthesized for the visualization and fluorescence analysis detection of phosgene. Through comparison, it was found that DHX-Phos-Pyr exhibited high selectivity and sensitivity, with response time of less than50 s detection limit of 32 nM in solution and gaseous phosgene detection limit of 0.31 ppm. The strong color difference and macroscopic red color have the function of stimulating people's senses and emotions. DHX-Phos-Pyr exhibits a clear color change from yellow to pink for the identification and analysis of phosgene solution by naked eye, and under 365 nm conditions, it displays a bright red color after responding to phosgene, serving as a strong warning. In addition, test strips loaded with DHX-Phos-Pyr were prepared and shown to possess practical utility for the sensitive fluorescence detection of phosgene.

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一种有效的二羟基蒽基荧光探针，用于光气液相视觉检测。

光气的实时监测对公众健康和环境安全具有重要意义。为了实现这一目标，提出了一种策略，通过引入具有不同吸电子能力的受体来调节分子内电荷转移（ICT），构建具有长激发/发射波长和高荧光量子产率的探针结构。在此基础上，设计合成了一类基于二羟基蒽染料的荧光探针DHX-Phos-Pyr （q.y = 7.91%）和DHX-Phos-BZT (q.y = 4.70%)，用于光气的可视化和荧光分析检测。通过对比发现，DHX-Phos-Pyr具有较高的选择性和灵敏度，响应时间小于50 s，溶液中检出限为32 nM，气态光气检出限为0.31 ppm。强烈的色差和宏观的红色具有刺激人的感官和情感的功能。DHX-Phos-Pyr在光气溶液的肉眼识别和分析中，呈现出从黄色到粉红色的清晰颜色变化，在365 nm条件下，对光气产生反应后呈现出明亮的红色，具有强烈的警示作用。此外，制备了负载DHX-Phos-Pyr的试纸条，并证明其具有光气敏感荧光检测的实用价值。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.