Maternal and Neonatal Outcomes for Pregnancies Complicated by Type 2 Diabetes and Polycystic Ovary Syndrome

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Canadian Journal of Diabetes Pub Date : 2026-07-01 Epub Date: 2026-03-18 DOI:10.1016/j.jcjd.2026.03.003

Jamie L. Benham MD, PhD, Sheldon Cannon MD, Kianna Cadogan MD, Hannah C. Botkin BSc, Samin Dolatabadi MD, Lenka Stafl MD, Jennifer M. Yamamoto MD, MSc

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引用次数: 0

Abstract

Objectives

Our aim in this study was to determine the prevalence of polycystic ovary syndrome (PCOS) among pregnancies affected by type 2 diabetes (T2D) and explore its relationship with maternal and neonatal outcomes.

Methods

Pregnancies affected by T2D from the Calgary Diabetes in Pregnancy program from 2008 to 2020 were chart reviewed for presence of PCOS, using logistic regression to examine associations between PCOS and maternal and neonatal outcomes.

Results

The prevalence of PCOS in pregnancies affected by T2D was 134 of 897 (14.9%). Compared with pregnancies affected by T2D alone, pregnancies affected by PCOS and T2D had higher odds of nulliparity (odds ratio [OR] 2.09, 95% confidence interval [CI] 1.44 to 3.02), prepregnancy weight ≥91 kg (OR 1.79, 95% CI 1.23, 2.60), preconception care (OR 2.79, 95% CI 1.77 to 4.40), and metformin use (OR 2.01, 95% CI 1.37 to 2.93). They also had lower odds of maternal age ≥35 years (OR 0.68, 95% CI 0.46 to 0.99), singleton pregnancy (OR 0.29, 95% CI 0.11 to 0.75), and insulin use (OR 0.60, 95% CI 0.39 to 0.93). There were no statistically significant differences between groups for neonatal outcomes.

Conclusions

The prevalence of PCOS among our cohort of pregnant women with T2D was lower than the reported prevalence of PCOS among women with T2D, perhaps reflecting the subfertility PCOS can confer. This may also explain the association with PCOS and nulliparity. People with PCOS were also more likely to receive preconception care and metformin treatment.

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妊娠合并2型糖尿病和多囊卵巢综合征的产妇和新生儿结局

目的：了解2型糖尿病（T2D）孕妇多囊卵巢综合征（PCOS）的患病率，并探讨其与孕产妇和新生儿结局的关系。方法：对2008-2020年卡尔加里妊娠糖尿病项目中受T2D影响的妊娠进行图表回顾，以确定多囊卵巢综合征（PCOS）的存在，并使用logistic回归分析多囊卵巢综合征与孕产妇和新生儿结局之间的关系。结果：妊娠合并T2D的PCOS患病率为134/897（14.9%）。与单独受T2D影响的妊娠相比，PCOS和T2D影响的妊娠出现无产（OR 2.09, 95% CI 1.44, 3.02）、孕前体重≥91kg （OR 1.79, 95% CI 1.23, 2.60）、孕前护理（OR 2.79, 95% CI 1.77, 4.40）和二甲双胍使用（OR 2.01, 95% CI 1.37, 2.93）的几率更高。母亲年龄≥35岁（OR 0.68, 95% CI 0.46, 0.99）、单胎妊娠（OR 0.29, 95% CI 0.11, 0.75）和使用胰岛素（OR 0.60, 95% CI 0.39, 0.93）的几率较低。两组新生儿结局无统计学显著差异。结论：在我们的T2D孕妇队列中，PCOS的患病率低于报道的T2D女性中PCOS的患病率，这可能反映了PCOS可能导致的生育能力低下。这也可以解释与多囊卵巢综合征和不孕的关系。多囊卵巢综合征患者也更有可能接受孕前护理和二甲双胍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

4.00%

发文量

130

审稿时长

54 days

期刊介绍： The Canadian Journal of Diabetes is Canada''s only diabetes-oriented, peer-reviewed, interdisciplinary journal for diabetes health-care professionals. Published bimonthly, the Canadian Journal of Diabetes contains original articles; reviews; case reports; shorter articles such as Perspectives in Practice, Practical Diabetes and Innovations in Diabetes Care; Diabetes Dilemmas and Letters to the Editor.