CD4-CD8-T Cell Reconstitution Combined with Acute GVHD and CMV Infection: A Robust Predictor of Overall Survival and Non-Relapse Mortality After HSCT.

IF 2.3 4区医学 Q3 IMMUNOLOGY

Immunological Investigations Pub Date : 2026-07-01 Epub Date: 2026-03-21 DOI:10.1080/08820139.2026.2647057

Xiaoling Wang, Liang Zhao, Chao Han, Guimin Yang, Lixiao Cai

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引用次数: 0

Abstract

Background: Immune reconstitution (IR), acute graft-versus-host disease (aGVHD), and cytomegalovirus (CMV) infection are all crucial factors influencing the prognosis following hematopoietic stem cell transplantation (HSCT).

Methods: A cohort of 116 pediatric patients undergoing HSCT was divided into two groups: those with aGVHD+CMV+ (DP group) and those without this combination (NDP group). Kaplan-Meier (KM) curves were generated to compare survival differences between the groups. Logistic regression analysis was performed to identify associations between IR and aGVHD+CMV+. Cox proportional hazards regression analysis was conducted to determine the independent risk factors affecting prognosis.

Results: The prognosis of DP group was significantly worse than that of the NDP group. Notable disparities in lymphocyte subset levels were observed between the DP and NDP groups. The level of CD4-CD8-T cells showed a significant correlation with the co-occurrence of aGVHD and CMV infection. Impaired reconstitution of CD4-CD8-T cells and aGVHD+CMV+ were found to be independent risk factors for post-HSCT survival. Patients in DP group with CD4-CD8-T cell counts > 49 cells/µl (at day 90 post-HSCT) demonstrated a significantly improved prognosis.

Conclusions: Elevated CD4-CD8-T cell counts may mitigate the adverse effects of aGVHD and CMV infection on HSCT outcomes, suggesting their potential as a prognostic biomarker.

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CD4-CD8-T细胞重构联合急性GVHD和CMV感染：HSCT后总生存率和非复发死亡率的可靠预测因子

背景：免疫重建（IR）、急性移植物抗宿主病（aGVHD）和巨细胞病毒（CMV）感染都是影响造血干细胞移植（HSCT）术后预后的重要因素。方法：116例接受HSCT的儿童患者被分为两组：aGVHD+CMV+组（DP组）和无aGVHD+CMV+组（NDP组）。生成Kaplan-Meier （KM）曲线来比较各组之间的生存差异。Logistic回归分析确定IR与aGVHD+CMV+之间的关系。采用Cox比例风险回归分析确定影响预后的独立危险因素。结果：DP组预后明显差于NDP组。淋巴细胞亚群水平在DP组和NDP组之间存在显著差异。CD4-CD8-T细胞水平与aGVHD和CMV感染同时发生有显著相关性。发现CD4-CD8-T细胞重构受损和aGVHD+CMV+是hsct后生存的独立危险因素。DP组患者CD4-CD8-T细胞计数为bb1049个/µl （hsct后第90天），预后明显改善。结论：CD4-CD8-T细胞计数升高可能减轻aGVHD和CMV感染对HSCT结果的不良影响，提示它们可能作为预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunological Investigations 医学-免疫学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.