Benoxinate-Induced Keratopathy: Clinical Patterns and Management, a Cairo University Residents' Report.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-05-01 Epub Date: 2026-03-20 DOI:10.1097/ICL.0000000000001265

Maryam Massoud, Rawan Hosny, Rana Shebl, Maha Saad, Bassant Yasser, Fayrouz Aboalazayem, Ahmed Rashad Ashor, Mohamed Hosny, Yehia Salah Mostafa

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引用次数: 0

Abstract

Purpose: To describe clinical characteristics, patterns, and management options in benoxinate-induced keratopathy.

Methods: Retrospective single-center study in which patients using benoxinate hydrochloride 0.4% for greater than 1 month and present with keratopathy and/or corneal complications were enrolled.

Results: A total of 36 eyes were included, 90.5% belonged to welders. Median corrected distance visual acuity (CDVA) was 2.3 logMAR (hand motion). Secondary corneal abscess was present in 47.2% of eyes and 66.7% of eyes showed ring-shaped corneal deposits. Approximately 13.9% had corneal perforation at presentation and 22.3% had marked corneal thinning. All eyes except one had varying degrees of epithelial defects, mean defect 50.7±38.1 mm 2 . Approximately 47.2% received medical treatment and 52.7% were treated surgically. Size of epithelial defect was correlated to CDVA and presence of abscess ( P =0.007 and 0.041). Choice of management was affected by size of epithelial defect and CDVA ( P <0.001 and=0.006). CDVA did not improve after reepithelialization ( P =0.157).

Conclusion: Benoxinate-induced keratopathy is a potentially blinding and preventable disease. Stricter laws preventing over the counter availability is needed.

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苯氧辛酸诱发的角膜病变：临床模式和管理，开罗大学居民报告。

目的：描述苯氧膦酸盐引起的角膜病变的临床特征、模式和治疗选择。方法：回顾性单中心研究，纳入使用盐酸苯氧酸盐0.4%超过1个月并出现角膜病变和/或角膜并发症的患者。结果：共纳入36只眼，其中焊工眼占90.5%。中位矫正距离视力（CDVA）为2.3 logMAR（手部运动）。继发性角膜脓肿发生率为47.2%，环状角膜沉积发生率为66.7%。约13.9%的患者就诊时角膜穿孔，22.3%的患者角膜明显变薄。除1只眼外，其余眼均有不同程度的上皮缺损，平均缺损50.7±38.1 mm2。约47.2%接受了内科治疗，52.7%接受了手术治疗。上皮缺损的大小与CDVA和脓肿的存在相关（P=0.007和0.041）。结论：苯氧膦酸盐引起的角膜病变是一种潜在的致盲性疾病，可预防。需要更严格的法律来防止非处方药的可用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.