Revolutionizing vision using corneal 3D printing.

IF 16.6 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2026-10-01 Epub Date: 2026-03-18 DOI:10.1016/j.tibtech.2026.01.019

Bowen Zhang, F A Dain Md Opo, Daniel Nahra, James Chodosh, Miguel Gonzalez-Andrades, Mohammad Mirazul Islam, Hirak K Patra

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引用次数: 0

Abstract

Corneal diseases remain a leading cause of blindness, and corneal transplantation is the primary treatment for severe cases. However, the persistent shortage of donor corneas significantly limits this approach. Artificial corneas with engineered biomaterials designed to mimic the structure and function of native corneal tissue offer a promising alternative, and significant progress has been made, including FDA approval and clinical trials. Among emerging technologies, 3D printing enables personalized customization of implants tailored to patient needs, anatomy, and pathology. This method also enables precise control over the biomaterial composition and integration of living cells within the implant, enhancing post-transplantation regeneration. In this review, we examine the advancements in 3D-printed, proregenerative artificial corneas, focusing on innovative biofabrication and the challenges that remain in ensuring implant quality.

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使用角膜3D打印革新视力。

角膜疾病仍然是导致失明的主要原因，角膜移植是严重病例的主要治疗方法。然而，供体角膜的持续短缺极大地限制了这种方法。人造角膜采用工程生物材料来模拟天然角膜组织的结构和功能，这是一个很有前途的选择，并且已经取得了重大进展，包括FDA的批准和临床试验。在新兴技术中，3D打印使植入物能够根据患者的需求、解剖结构和病理进行个性化定制。这种方法还可以精确控制生物材料的组成和植入物内活细胞的整合，增强移植后的再生。在这篇综述中，我们研究了3d打印，促再生人工角膜的进展，重点是创新的生物制造和在确保植入物质量方面仍然存在的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).