Plasma proteomic trajectories before the onset of neurodegenerative diseases.

IF 3.4 Q3 CLINICAL NEUROLOGY

Neurodegenerative disease management Pub Date : 2026-03-19 DOI:10.1080/17582024.2026.2646760

Zhihan Zhang, Rui Fan, Sisi Jing, Shiyi Liu, Linqi Liu, Wenjun Que, Dan Lu, Yaoqi Gan, Fei Xiao

{"title":"Plasma proteomic trajectories before the onset of neurodegenerative diseases.","authors":"Zhihan Zhang, Rui Fan, Sisi Jing, Shiyi Liu, Linqi Liu, Wenjun Que, Dan Lu, Yaoqi Gan, Fei Xiao","doi":"10.1080/17582024.2026.2646760","DOIUrl":null,"url":null,"abstract":"Background: The study aimed to identify indicative proteins associated with the occurrence and mortality of three neurodegenerative diseases (NDDs) and track the changes of proteins before the onset of NDDs.Research design and methods: We analyzed plasma proteomic data from UK Biobank. Cox regression analyses were utilized to detect the relationship between plasma proteins and the risk of development and all-cause mortality of Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Predictive models were established based on related proteins using Lasso regression.Results: We identified 14 disease-associated proteins for AD, 35 for PD, and one for ALS. The trajectory of plasma proteins before the onset of NDDs was portrayed. Neuroinflammation and the remodeling of the extracellular matrix might be common pathways for NDDs.Conclusions: Our results highlighted that the landscape of plasma protein changes before the onset of NDDs.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"1-12"},"PeriodicalIF":3.4000,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurodegenerative disease management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17582024.2026.2646760","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The study aimed to identify indicative proteins associated with the occurrence and mortality of three neurodegenerative diseases (NDDs) and track the changes of proteins before the onset of NDDs.

Research design and methods: We analyzed plasma proteomic data from UK Biobank. Cox regression analyses were utilized to detect the relationship between plasma proteins and the risk of development and all-cause mortality of Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Predictive models were established based on related proteins using Lasso regression.

Results: We identified 14 disease-associated proteins for AD, 35 for PD, and one for ALS. The trajectory of plasma proteins before the onset of NDDs was portrayed. Neuroinflammation and the remodeling of the extracellular matrix might be common pathways for NDDs.

Conclusions: Our results highlighted that the landscape of plasma protein changes before the onset of NDDs.

查看原文本刊更多论文

神经退行性疾病发病前的血浆蛋白质组学轨迹。

背景：本研究旨在鉴定与三种神经退行性疾病（ndd）发生和死亡相关的指示性蛋白，并追踪ndd发病前蛋白的变化。研究设计和方法：我们分析了来自UK Biobank的血浆蛋白质组学数据。采用Cox回归分析检测血浆蛋白与阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩性侧索硬化症（ALS）的发病风险和全因死亡率之间的关系。利用Lasso回归建立了相关蛋白的预测模型。结果：我们鉴定出14种与AD相关的疾病蛋白，35种与PD相关，1种与ALS相关。描述了ndd发病前血浆蛋白的变化轨迹。神经炎症和细胞外基质的重塑可能是ndd的常见途径。结论：我们的研究结果强调了血浆蛋白在ndd发病前的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neurodegenerative disease management CLINICAL NEUROLOGY-

CiteScore

4.30

自引率

0.00%

发文量