Co-variation between blood stream infections with Candida species versus Pseudomonas aeruginosa, Staphylococcus aureus, and other isolates among 60 ICU patient cohorts.

IF 3.5 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2026-02-28 DOI:10.1093/mmy/myag023

James C Hurley

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引用次数: 0

Abstract

Background: Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcal species, Coagulase-negative Staphylococci, Acinetobacter species, and Candida species are common blood stream infection (BSI) isolates among intensive care unit (ICU) cohorts. That Candida species might interact with bacteria at mucosal surfaces to facilitate invasive infections prompts the question as to the degree of co-variance between Candida species versus bacteria among BSI isolates.

Objectives: To estimate the co-variance between Candida species versus each of these five bacteria as BSI isolates among ICU patient cohorts.

Methods: The literature was searched opportunistically for studies reporting ICU patient cohorts listing Candida species among BSI isolates. The associations of the BSI incidence proportion per 100 patients were converted to logits and modelled using ellipse plots.

Results: The median overall BSI incidence proportion was 7.8% (interquartile range; 4.8%-11.6%). Among 60 cohorts (50 publications), correlation with the incidence proportion of Candidemia was apparent for Acinetobacter species (correlation coefficient = 0.69), Staphylococcus aureus (0.47), and Pseudomonas aeruginosa (0.4) but less so for Coagulase-negative Staphylococci (0.37) and Enterococcal species (0.32).

Conclusions: There are various degrees of co-variance between the BSI incidence proportion amongst the five types of bacteria and Candida species among ICU cohorts.

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60例ICU患者血流感染念珠菌与铜绿假单胞菌、金黄色葡萄球菌等的共变异

背景：金黄色葡萄球菌、铜绿假单胞菌；肠球菌、凝固酶阴性葡萄球菌、不动杆菌和念珠菌是ICU队列中常见的血流感染（BSI）分离株。念珠菌物种可能与粘膜表面的细菌相互作用，从而促进侵袭性感染，这就提出了念珠菌物种与BSI分离株中细菌之间的协方差程度的问题。目的：估计在ICU患者队列中，念珠菌种类与这五种细菌作为BSI分离株之间的协方差。方法：机会性地检索ICU患者队列中列出BSI分离株中念珠菌种类的研究。每100例患者BSI发生率的关联被转换为对数，并使用椭圆图建模。结果：中位总体BSI发生率为7.8% （IQR; 4.8%-11.6%）。在60个队列（50篇出版物）中，不动杆菌种（0.69）、金黄色葡萄球菌（0.47）和铜绿假单胞菌（0.4）与念珠菌的发病率比例相关性明显，而凝固酶阴性葡萄球菌（0.37）和肠球菌（0.32）与念珠菌发病率比例相关性较低。结论：ICU队列中5种细菌和念珠菌的BSI发病率比例存在不同程度的协方差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.