CPAP to Reduce the Risk of Cancer in OSA?-A Meta-Analysis of 3 RCTs.

IF 3.9 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Sleep Research Pub Date : 2026-04-01 Epub Date: 2025-07-17 DOI:10.1111/jsr.70153

Jenny Theorell-Haglöw, Yüksel Peker, Nathaniel S Marshall

引用次数: 0

Abstract

Obstructive sleep apnea (OSA) has been hypothesised to promote cancer via intermittent hypoxia, and assessing what happens when OSA is controlled by continuous positive airway pressure (CPAP) may provide valuable insight. We conducted a meta-analysis of three randomised controlled trials (SAVE, RICCADSA, ISAACC) assessing cancer incidence from adverse event data on neoplasms among OSA patients randomised to continuous positive airway pressure (CPAP) versus control. Across trials, cancer incidence was similar between groups, and meta-analysis showed no statistically significant difference (CI 0.55-1.68). Treating sleep apnea with CPAP does not appear to markedly reduce the risk of incident cancers.

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CPAP可降低阻塞性睡眠呼吸暂停患者的癌症风险？- 3项随机对照试验的meta分析。

阻塞性睡眠呼吸暂停（OSA）已被假设通过间歇性缺氧促进癌症，评估当持续气道正压通气（CPAP）控制OSA时会发生什么可能提供有价值的见解。我们对三个随机对照试验（SAVE、RICCADSA、ISAACC）进行了荟萃分析，评估了随机接受持续气道正压通气（CPAP）治疗的OSA患者与对照组之间肿瘤不良事件数据的癌症发生率。在所有试验中，各组之间的癌症发病率相似，荟萃分析显示无统计学意义差异（CI 0.55-1.68）。用CPAP治疗睡眠呼吸暂停似乎不能显著降低发生癌症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Sleep Research 医学-临床神经学

CiteScore

9.00

自引率

6.80%

发文量

234

审稿时长

6-12 weeks

期刊介绍： The Journal of Sleep Research is dedicated to basic and clinical sleep research. The Journal publishes original research papers and invited reviews in all areas of sleep research (including biological rhythms). The Journal aims to promote the exchange of ideas between basic and clinical sleep researchers coming from a wide range of backgrounds and disciplines. The Journal will achieve this by publishing papers which use multidisciplinary and novel approaches to answer important questions about sleep, as well as its disorders and the treatment thereof.