Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease

IF 11 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI:10.1016/j.tibs.2026.01.005

Radhwan Al-Zidan , Manjul Gautam , Si Ming Man

引用次数: 0

Abstract

Recent work by Wang and colleagues reveals a unique mode of cell death called mitoxyperilysis, driven by mitochondrial proximity-dependent rupture of the plasma cell membrane. This lytic cell death is triggered by immune agonists combined with fasting or nutrient starvation, offering therapeutic implications in sepsis and cancer.

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线粒体坏死：免疫代谢和疾病中禁食诱导的细胞死亡。

Wang和他的同事们最近的工作揭示了一种独特的细胞死亡模式，称为线粒体坏死，由线粒体接近性依赖的浆细胞膜破裂驱动。这种溶解性细胞死亡是由免疫激动剂与禁食或营养饥饿联合引发的，在败血症和癌症中具有治疗意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.