The Odyssey of macrophages

IF 6.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2026-04-01 Epub Date: 2026-03-17 DOI:10.1016/j.bj.2026.100967

Aila Akosua Kattner

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引用次数: 0

Abstract

This issue brings together reviews and original research addressing diverse aspects of immune regulation, disease mechanisms, and clinical management. Several reviews focus on macrophages as integrative regulators across physiological systems, including their circadian control of immune activity, their role in coordinating endocrine signaling within the hypothalamic–pituitary axes, and their functions in cardiac tissue homeostasis and repair. Additional contributions revisit the development of regulatory T cells as a central mechanism of peripheral immune tolerance, examine the potential of artificial intelligence for infectious disease surveillance, and discuss emerging roles of long non-coding RNAs in cardiac regeneration. Further reviews evaluate multidisciplinary care strategies for pelvic floor disorders and analyze the inflammatory consequences of photodynamic therapy. Original studies in this issue investigate areca nut–associated head and neck carcinogenesis, determinants of persistent carbapenem-resistant Klebsiella pneumoniae bacteremia, treatment outcomes in hepatocellular carcinoma with portal vein tumor thrombus, protective effects against gastric ulceration, machine-learning–assisted interpretation of syphilis serology, and relapse patterns following orthognathic surgery.

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巨噬细胞的奥德赛

本刊汇集了免疫调节、疾病机制和临床管理等不同方面的综述和原始研究。一些综述关注巨噬细胞作为生理系统的综合调节因子，包括它们对免疫活动的昼夜节律控制，它们在协调下丘脑-垂体轴内分泌信号中的作用，以及它们在心脏组织稳态和修复中的功能。其他贡献回顾了作为外周免疫耐受中心机制的调节性T细胞的发展，研究了人工智能在传染病监测中的潜力，并讨论了长链非编码rna在心脏再生中的新作用。进一步的综述评估盆底疾病的多学科护理策略，并分析光动力治疗的炎症后果。这期杂志的原始研究调查了槟榔相关的头颈部癌变，持久性碳青霉烯耐药肺炎克雷伯菌血症的决定因素，肝细胞癌合并门静脉肿瘤血栓的治疗结果，对胃溃疡的保护作用，梅毒血清学的机器学习辅助解释，以及正颌骨手术后的复发模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.