Solving the mystery of vaccine-induced immune thrombocytopenia and thrombosis

IF 50.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2026-03-18 DOI:10.1038/s41569-026-01279-7

Julie Rayes, Jagadeesh Bayry

引用次数: 0

Abstract

Vaccine-induced immune thrombotic thrombocytopenia is a rare complication of adenoviral vector-based COVID-19 vaccines. New data show that vaccine-induced immune thrombotic thrombocytopenia arises from molecular mimicry between platelet factor 4 and adenoviral core protein VII after the acquisition of the K31E mutation in the IgG light chain in individuals who carry the IGLV3-21*02 or IGLV3-21*03 alleles.

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解决疫苗诱导的免疫性血小板减少症和血栓形成之谜。

疫苗诱导的免疫性血栓性血小板减少症是基于腺病毒载体的COVID-19疫苗的罕见并发症。新数据显示，在携带IGLV3-21*02或IGLV3-21*03等位基因的个体中，在获得IgG轻链K31E突变后，疫苗诱导的免疫性血栓性血小板减少是由血小板因子；4和腺病毒核心蛋白；VII之间的分子模仿引起的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.