Pulsed Dye Laser Versus Carboxytherapy for the Treatment of Stria Rubra: A Randomized Clinical and Histopathological Study.

IF 2.7 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI:10.1111/phpp.70080

Rana F Hilal, Aya Fahim, Amira Elbendary, Rawan Abumayyala

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引用次数: 0

Abstract

Background: Pulsed Dye Laser (PDL) and carboxytherapy target the vascular component of Stria Rubra (SR), followed by a secondary rejuvenating effect.

Objective: To compare the efficacy and safety of PDL and carboxytherapy for the treatment of SR.

Materials & methods: Twenty patients with SR were included in this study. Each patient received PDL to one randomly selected SR side and carboxytherapy to the other randomly selected SR side. Clinical outcome assessment was done using number of striae and maximum stria width, Vancouver Scar scale (VSS), Erythema index (EI), and histopathological evaluation.

Results: Significant improvement in VSS, EI, and histopathological scoring was found after treatment with each modality, whether PDL or carboxytherapy. Comparison between both modalities revealed a non-significant difference between PDL and carboxytherapy as regards VSS, EI, and histopathological scoring change. Histopathological analysis showed a significant increase of collagen and elastic fibres following PDL. Collagen fibres and perpendicular blood vessels increased significantly with carboxytherapy. PIH was encountered following PDL.

Conclusion: Both PDL and carboxytherapy are effective for the treatment of SR. PDL is proposed to produce a better outcome as regards improving the texture of SR skin. The risk of pigmentation can be avoided by proper PDL dosage.

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脉冲染料激光与羧基疗法治疗红纹：一项随机临床和组织病理学研究。

背景：脉冲染料激光（PDL）和羧基疗法针对红纹（SR）的血管成分，随后产生二次恢复青春的效果。目的：比较PDL与carboxytherapy治疗SR的疗效和安全性。材料与方法：选取20例SR患者。每位患者随机选择一侧SR侧接受PDL治疗，另一侧随机选择一侧SR侧接受羧基治疗。临床结果评估采用斑纹数和最大斑纹宽度、温哥华疤痕评分（VSS）、红斑指数（EI）和组织病理学评估。结果：无论是PDL还是羧基治疗，每一种治疗方式均能显著改善VSS、EI和组织病理学评分。两种治疗方式的比较显示PDL和羧基治疗在VSS、EI和组织病理学评分变化方面无显著差异。组织病理学分析显示PDL后胶原蛋白和弹性纤维明显增加。胶原纤维和垂直血管明显增加。PDL后出现PIH。结论：PDL与羧酸疗法治疗SR均有效，PDL在改善SR皮肤质地方面效果更好。适当的PDL剂量可以避免色素沉着的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.