Chronic Kidney Disease, Sarcopenia, and Hormonal-Metabolic Alterations: An Intriguing Association.

IF 2.1 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2026-01-01 Epub Date: 2026-03-17 DOI:10.1159/000551499

Alessandro Domenico Quercia, Beatrice Cavigiolo, Chiara Mele

{"title":"Chronic Kidney Disease, Sarcopenia, and Hormonal-Metabolic Alterations: An Intriguing Association.","authors":"Alessandro Domenico Quercia, Beatrice Cavigiolo, Chiara Mele","doi":"10.1159/000551499","DOIUrl":null,"url":null,"abstract":"Background: Sarcopenia is a common yet underrecognized complication of chronic kidney disease (CKD), often affecting younger patients and progressing more rapidly than age-related muscle loss. It is driven by a combination of metabolic, hormonal, and inflammatory abnormalities associated with declining renal function.Summary: This review outlines the key mechanisms linking CKD to sarcopenia, including metabolic acidosis, uremic toxin accumulation, hormonal dysregulation, insulin resistance, and chronic inflammation. These factors impair muscle protein turnover and promote protein-energy wasting. The review also discusses diagnostic limitations and emerging therapeutic strategies, such as individualized nutrition, resistance training, and gut microbiota modulation.Key messages: Sarcopenia in CKD contributes to increased morbidity and mortality. Early identification and personalized, multidisciplinary interventions are essential to preserve muscle health and improve patient outcomes.","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"312-325"},"PeriodicalIF":2.1000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13221173/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney & blood pressure research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000551499","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Sarcopenia is a common yet underrecognized complication of chronic kidney disease (CKD), often affecting younger patients and progressing more rapidly than age-related muscle loss. It is driven by a combination of metabolic, hormonal, and inflammatory abnormalities associated with declining renal function.

Summary: This review outlines the key mechanisms linking CKD to sarcopenia, including metabolic acidosis, uremic toxin accumulation, hormonal dysregulation, insulin resistance, and chronic inflammation. These factors impair muscle protein turnover and promote protein-energy wasting. The review also discusses diagnostic limitations and emerging therapeutic strategies, such as individualized nutrition, resistance training, and gut microbiota modulation.

Key messages: Sarcopenia in CKD contributes to increased morbidity and mortality. Early identification and personalized, multidisciplinary interventions are essential to preserve muscle health and improve patient outcomes.

查看原文本刊更多论文

慢性肾脏疾病、肌肉减少症和激素代谢改变：一个有趣的关联。

背景：肌肉减少症是慢性肾脏疾病（CKD）的一种常见但未被充分认识的并发症，通常影响年轻患者，并且比年龄相关的肌肉损失进展更快。它是由与肾功能下降相关的代谢、激素和炎症异常共同驱动的。摘要：本文概述了CKD与肌肉减少症相关的关键机制，包括代谢性酸中毒、尿毒症毒素积累、激素失调、胰岛素抵抗和慢性炎症。这些因素损害肌肉蛋白质的周转，促进蛋白质能量的浪费（PEW）。该综述还讨论了诊断局限性和新兴的治疗策略，如个体化营养、阻力训练和肠道微生物群调节。关键信息：慢性肾病患者的肌肉减少会增加发病率和死亡率。早期识别和个性化的多学科干预对于保持肌肉健康和改善患者预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.