[Choroidal Tumors].

IF 1.1 4区 医学 Q4 OPHTHALMOLOGY
Klinische Monatsblatter fur Augenheilkunde Pub Date : 2026-08-01 Epub Date: 2026-03-17 DOI:10.1055/a-2680-5849
Miltiadis Fiorentzis, Nikolaos E Bechrakis, Tobias Kiefer
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引用次数: 0

Abstract

Abstract: Choroidal tumors comprise a heterogeneous group of intraocular lesions ranging from benign entities such as choroidal nevus and circumscribed choroidal hemangioma to malignant tumors including uveal melanoma and choroidal metastasis. Accurate differentiation is crucial, as management and prognosis exhibit significant variations.Choroidal nevi are the most prevalent benign intraocular tumors and are generally asymptomatic. However, a small subset of these nevi carries a risk of malignant transformation into melanoma. Risk stratification utilizing multimodal imaging criteria, such as the TFSOM-DIM and MOLES systems, is pivotal in clinical decision-making.Uveal melanoma represents the most common primary intraocular malignancy in adults and is associated with high metastasis rates, particularly to the liver. Prognosis depends on tumor size, location, histopathologic features, and molecular alterations such as monosomy 3 or BAP1 loss. Treatment options range from globe-preserving radiotherapy to adjuvant or neoadjuvant surgical resection and enucleation in advanced cases.Choroidal hemangioma is a benign vascular tumor that can lead to visual impairment due to exudative retinal detachment. Photodynamic therapy is currently considered the preferred treatment in symptomatic cases.Choroidal metastases represent the most prevalent intraocular malignancies, with a primary origin in breast or lung carcinoma. Multimodal imaging is essential for diagnosis and monitoring, and management requires interdisciplinary coordination.A structured multimodal diagnostic approach is crucial for accurate classification, risk assessment, and individualized therapeutic planning in patients with choroidal tumors.

脉络膜的肿瘤。
脉络膜肿瘤包括一组异质性的眼内病变,从良性实体如脉络膜痣和边界脉络膜血管瘤到恶性肿瘤包括葡萄膜黑色素瘤和脉络膜转移。准确的鉴别是至关重要的,因为管理和预后表现出显著的差异。脉络膜痣是最常见的良性眼内肿瘤,通常无症状。然而,这些痣中的一小部分有恶性转化为黑色素瘤的风险。利用多模态成像标准(如TFSOM-DIM和mole系统)进行风险分层在临床决策中至关重要。葡萄膜黑色素瘤是成人中最常见的原发性眼内恶性肿瘤,具有高转移率,特别是肝脏转移率高。预后取决于肿瘤大小、位置、组织病理特征和分子改变,如单体3或BAP1丢失。治疗选择范围从保球体放射治疗到辅助或新辅助手术切除和晚期病例的去核。脉络膜血管瘤是一种良性血管肿瘤,可因渗出性视网膜脱离而导致视力损害。光动力疗法目前被认为是有症状病例的首选治疗方法。脉络膜转移是最常见的眼内恶性肿瘤,原发于乳腺癌或肺癌。多模态成像对诊断和监测至关重要,管理需要跨学科协调。结构化的多模式诊断方法对于脉络膜肿瘤患者的准确分类、风险评估和个性化治疗计划至关重要。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
235
审稿时长
4-8 weeks
期刊介绍: -Konzentriertes Fachwissen aus Klinik und Praxis: Die entscheidenden Ergebnisse der internationalen Forschung - für Sie auf den Punkt gebracht und kritisch kommentiert, Übersichtsarbeiten zu den maßgeblichen Themen der täglichen Praxis, Top informiert - breite klinische Berichterstattung. -CME-Punkte sammeln mit dem Refresher: Effiziente, CME-zertifizierte Fortbildung, mit dem Refresher, 3 CME-Punkte pro Ausgabe - bis zu 36 CME-Punkte im Jahr!. -Aktuelle Rubriken mit echtem Nutzwert: Kurzreferate zu den wichtigsten Artikeln internationaler Zeitschriften, Schwerpunktthema in jedem Heft: Ausführliche Übersichtsarbeiten zu den wichtigsten Themen der Ophthalmologie – so behalten Sie das gesamte Fach im Blick!, Originalien mit den neuesten Entwicklungen, Übersichten zu den relevanten Themen.
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