{"title":"Recurrence and related factors associated with uterine leiomyoma following laparoscopic myomectomy: a meta-analysis.","authors":"Jun Zhao, Lei Zhang, Huan Zhao, Xiaolin Ma","doi":"10.1080/13645706.2026.2643432","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is still no clear consensus on long-term follow-up data for uterine leiomyoma (UL) recurrence and the major risk factors for recurrence after UL resection. This study aimed to investigate UL recurrence and related factors after laparoscopic myomectomy (LM).</p><p><strong>Methods: </strong>The local and international literature on UL recurrence rates and related factors after LM was systematically collected, with the search period up to December 31st, 2024. Stata 16.0 software was used for meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model with the Hartung-Knapp-Sidik-Jonkman adjustment, regardless of the I<sup>2</sup>value.</p><p><strong>Results: </strong>A total of eight studies were included, and 2,160 patients receiving LM were followed up for more than 12 months. The total number of recurrence cases was 497, and the crude recurrence rate was 23.0%. The meta-analysis results indicated that preoperative UL size ≥ 10 cm (OR = 2.15, <i>p</i> < 0.001), uterine size >10 or 14 weeks (OR = 2.40, <i>p</i> = 0.001), and preoperative UL number ≥2 (OR = 2.46, <i>p</i> < 0.001) were risk factors for UL recurrence after LM. There was no statistically significant association between age ≥35 years, BMI ≥ 24 or 25 kg/m<sup>2</sup>, postoperative delivery or pregnancy, and post-LM UL recurrence.</p><p><strong>Conclusions: </strong>In this study, the risk factors for UL recurrence after LM were obtained through meta-analysis, which is more stable and reliable than the results of a single study and can provide a reference and basis for clinically identifying the risk factors related to LM recurrence after surgery, fully evaluating the risk of recurrence before surgery and predicting high-risk groups.</p>","PeriodicalId":18537,"journal":{"name":"Minimally Invasive Therapy & Allied Technologies","volume":" ","pages":"210-220"},"PeriodicalIF":1.8000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minimally Invasive Therapy & Allied Technologies","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13645706.2026.2643432","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: There is still no clear consensus on long-term follow-up data for uterine leiomyoma (UL) recurrence and the major risk factors for recurrence after UL resection. This study aimed to investigate UL recurrence and related factors after laparoscopic myomectomy (LM).
Methods: The local and international literature on UL recurrence rates and related factors after LM was systematically collected, with the search period up to December 31st, 2024. Stata 16.0 software was used for meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model with the Hartung-Knapp-Sidik-Jonkman adjustment, regardless of the I2value.
Results: A total of eight studies were included, and 2,160 patients receiving LM were followed up for more than 12 months. The total number of recurrence cases was 497, and the crude recurrence rate was 23.0%. The meta-analysis results indicated that preoperative UL size ≥ 10 cm (OR = 2.15, p < 0.001), uterine size >10 or 14 weeks (OR = 2.40, p = 0.001), and preoperative UL number ≥2 (OR = 2.46, p < 0.001) were risk factors for UL recurrence after LM. There was no statistically significant association between age ≥35 years, BMI ≥ 24 or 25 kg/m2, postoperative delivery or pregnancy, and post-LM UL recurrence.
Conclusions: In this study, the risk factors for UL recurrence after LM were obtained through meta-analysis, which is more stable and reliable than the results of a single study and can provide a reference and basis for clinically identifying the risk factors related to LM recurrence after surgery, fully evaluating the risk of recurrence before surgery and predicting high-risk groups.
背景：对于子宫平滑肌瘤（UL）切除术后复发的长期随访资料和主要危险因素，目前尚无明确的共识。本研究旨在探讨腹腔镜子宫肌瘤切除术（LM）后UL复发及相关因素。方法：系统收集国内外关于LM术后UL复发率及相关因素的文献，检索期截止到2024年12月31日。采用Stata 16.0软件进行meta分析。无论i2值如何，使用Hartung-Knapp-Sidik-Jonkman调整的随机效应模型计算95%置信区间（ci）的合并优势比（ORs）。结果：共纳入8项研究，2160例接受LM的患者随访超过12个月。总复发病例497例，粗复发率23.0%。meta分析结果显示，术前UL尺寸≥10 cm (OR = 2.15, p = 10或14周（OR = 2.40, p = 0.001），术前UL数≥2 （OR = 2.46, p = 2）与术后分娩或妊娠、lm后UL复发有关。结论：本研究通过荟萃分析获得LM术后UL复发的危险因素，比单一研究结果更加稳定可靠，可为临床识别LM术后复发相关危险因素、术前充分评估复发风险、预测高危人群提供参考和依据。
期刊介绍：
Minimally Invasive Therapy and Allied Technologies (MITAT) is an international forum for endoscopic surgeons, interventional radiologists and industrial instrument manufacturers. It is the official journal of the Society for Medical Innovation and Technology (SMIT) whose membership includes representatives from a broad spectrum of medical specialities, instrument manufacturing and research. The journal brings the latest developments and innovations in minimally invasive therapy to its readers. What makes Minimally Invasive Therapy and Allied Technologies unique is that we publish one or two special issues each year, which are devoted to a specific theme. Key topics covered by the journal include: interventional radiology, endoscopic surgery, imaging technology, manipulators and robotics for surgery and education and training for MIS.
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